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RLF2 Rlf2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 856129, updated on 18-Sep-2024

Summary

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Official Symbol
RLF2
Official Full Name
Rlf2p
Primary source
SGD:S000006222
Locus tag
YPR018W
See related
AllianceGenome:SGD:S000006222; FungiDB:YPR018W; VEuPathDB:YPR018W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
CAC1
Summary
Contributes to histone binding activity. Involved in DNA replication-dependent chromatin assembly. Located in chromosome, centromeric region and nucleus. Part of CAF-1 complex. Colocalizes with chromatin. Human ortholog(s) of this gene implicated in colon cancer; high grade glioma; neuroblastoma; and systemic lupus erythematosus. Orthologous to human CHAF1A (chromatin assembly factor 1 subunit A). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See RLF2 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (594476..596296)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene translation initiation factor 6 Neighboring gene guanine nucleotide exchange factor DSS4 Neighboring gene MCM DNA helicase complex subunit MCM4 Neighboring gene F1F0 ATP synthase subunit g

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The yeast Cac1 protein is required for the stable inheritance of transcriptionally repressed chromatin at telomeres. Monson EK, et al. Proc Natl Acad Sci U S A, 1997 Nov 25. PMID 9371803, Free PMC Article
  2. RLF2, a subunit of yeast chromatin assembly factor-I, is required for telomeric chromatin function in vivo. Enomoto S, et al. Genes Dev, 1997 Feb 1. PMID 9030688
  3. Dysfunctional CAF-I reveals its role in cell cycle progression and differential regulation of gene silencing. Rowlands H, et al. Cell Cycle, 2019 Nov. PMID 31564230, Free PMC Article
  4. Establishment of a promoter-based chromatin architecture on recently replicated DNA can accommodate variable inter-nucleosome spacing. Fennessy RT, et al. Nucleic Acids Res, 2016 Sep 6. PMID 27106059, Free PMC Article
  5. Analysis of epigenetic stability and conversions in Saccharomyces cerevisiae reveals a novel role of CAF-I in position-effect variegation. Jeffery DC, et al. Nucleic Acids Res, 2013 Oct. PMID 23863839, Free PMC Article

See all (164) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cac1 WHD and PIP domains have distinct roles in replisome progression and genomic stability.
    Title: Cac1 WHD and PIP domains have distinct roles in replisome progression and genomic stability.
  2. Dysfunctional CAF-I reveals its role in cell cycle progression and differential regulation of gene silencing.
    Title: Dysfunctional CAF-I reveals its role in cell cycle progression and differential regulation of gene silencing.
  3. CAF-1 and Asf1 function redundantly to deactivate the checkpoint by restoring chromatin structure on the completion of DNA double-strand break repair.
    Title: Chromatin assembly factors Asf1 and CAF-1 have overlapping roles in deactivating the DNA damage checkpoint when DNA repair is complete.
  4. Cac1p and Kap123 cooperate to ensure that only appropriately acetylated histone H4 proteins are imported into the nucleus
    Title: Yeast chromatin assembly complex 1 protein excludes nonacetylatable forms of histone H4 from chromatin and the nucleus.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
contributes_to histone binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA replication-dependent chromatin assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in DNA replication-dependent chromatin assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nucleosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of CAF-1 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of CAF-1 complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromosome, centromeric region IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Rlf2p
NP_015343.1
  • Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1); chromatin assembly by CAF-1 is important for multiple processes including histone H3/H4 tetramerization, silencing at telomeres, mating type loci and rDNA, maintenance of kinetochore structure, deactivation of DNA damage checkpoint after DNA repair, chromatin dynamics during transcription, and repression of divergent noncoding transcription

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    594476..596296
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184115.1 → NP_015343.1  TPA: Rlf2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015343.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W428, Q12495
    UniProtKB/TrEMBL
    A6ZWR1, B3LL79, B5VTH6, C8ZJ43, N1NXG2
    Conserved Domains (1) summary
    pfam12253
    Location:345 → 387
    CAF1A; Chromatin assembly factor 1 subunit A
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12495.1

Gene LinkOut

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