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NTO1 Nto1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 856143, updated on 29-Jun-2024

Summary

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Gene symbol
NTO1
Gene description
Nto1p
Primary source
FungiDB:YPR031W
Locus tag
YPR031W
See related
SGD:S000006235; AllianceGenome:SGD:S000006235; VEuPathDB:YPR031W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables methylated histone binding activity. Involved in histone acetylation. Located in cytoplasm and nucleus. Part of NuA3a histone acetyltransferase complex and NuA3b histone acetyltransferase complex. Human ortholog(s) of this gene implicated in bipolar disorder and schizophrenia. Orthologous to several human genes including BRPF1 (bromodomain and PHD finger containing 1); BRPF3 (bromodomain and PHD finger containing 3); and BRD1 (bromodomain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See NTO1 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (631515..633761)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Apl4p Neighboring gene Csr2p Neighboring gene Rab GTPase-binding protein SRO7 Neighboring gene histidine--tRNA ligase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Yng1 PHD finger binding to H3 trimethylated at K4 promotes NuA3 HAT activity at K14 of H3 and transcription at a subset of targeted ORFs. Taverna SD, et al. Mol Cell, 2006 Dec 8. PMID 17157260, Free PMC Article
  2. H3 k36 methylation helps determine the timing of cdc45 association with replication origins. Pryde F, et al. PLoS One, 2009 Jun 12. PMID 19521516, Free PMC Article
  3. Mapping the local protein interactome of the NuA3 histone acetyltransferase. Smart SK, et al. Protein Sci, 2009 Sep. PMID 19621382, Free PMC Article
  4. NuA3 HAT antagonizes the Rpd3S and Rpd3L HDACs to optimize mRNA and lncRNA expression dynamics. Kim JH, et al. Nucleic Acids Res, 2020 Nov 4. PMID 33010166, Free PMC Article
  5. Proteome-wide analysis in Saccharomyces cerevisiae identifies several PHD fingers as novel direct and selective binding modules of histone H3 methylated at either lysine 4 or lysine 36. Shi X, et al. J Biol Chem, 2007 Jan 26. PMID 17142463, Free PMC Article

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables methylated histone binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromatin remodeling IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of NuA3 histone acetyltransferase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of NuA3a histone acetyltransferase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of NuA3b histone acetyltransferase complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Nto1p
NP_015356.1
  • Subunit of the NuA3 histone acetyltransferase complex; this complex acetylates histone H3; contains PHD finger domain that interacts with methylated histone H3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    631515..633761
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184128.1 → NP_015356.1  TPA: Nto1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015356.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W441, Q12311
    UniProtKB/TrEMBL
    A0A8H4BUD1, B3LL92, B5VTI8, C7GQA7, C8ZJ55, N1P216
    Conserved Domains (1) summary
    COG5141
    Location:18 → 748
    COG5141; PHD zinc finger-containing protein [General function prediction only]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12311.1

Gene LinkOut

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