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ARP7 Arp7p [ Saccharomyces cerevisiae S288C ]

Gene ID: 856146, updated on 29-Jun-2024

Summary

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Gene symbol
ARP7
Gene description
Arp7p
Primary source
FungiDB:YPR034W
Locus tag
YPR034W
See related
SGD:S000006238; AllianceGenome:SGD:S000006238; VEuPathDB:YPR034W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
RSC11; SWP61
Summary
Predicted to enable chromatin binding activity. Involved in nucleosome organization; positive regulation of transcription by RNA polymerase II; and transcription elongation from RNA polymerase II promoter. Located in nucleus. Part of RSC-type complex and SWI/SNF complex. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 76. Orthologous to human ACTL6A (actin like 6A) and ACTL6B (actin like 6B). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See ARP7 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (639525..640958)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Rab GTPase-binding protein SRO7 Neighboring gene histidine--tRNA ligase Neighboring gene glutamate--ammonia ligase Neighboring gene H(+)-transporting V1 sector ATPase subunit H

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structure of the full-length yeast Arp7-Arp9 heterodimer. Lobsiger J, et al. Acta Crystallogr D Biol Crystallogr, 2014 Feb. PMID 24531465
  2. Two actin-related proteins are shared functional components of the chromatin-remodeling complexes RSC and SWI/SNF. Cairns BR, et al. Mol Cell, 1998 Nov. PMID 9844636
  3. The haploinsufficiency profile of α-hederin suggests a caspofungin-like antifungal mode of action. Prescott TA, et al. Phytochemistry, 2014 May. PMID 24569176
  4. Allosteric interactions of DNA and nucleotides with S. cerevisiae RSC. Malik SS, et al. Biochemistry, 2011 Sep 20. PMID 21834590, Free PMC Article
  5. The Swi2/Snf2 bromodomain is required for the displacement of SAGA and the octamer transfer of SAGA-acetylated nucleosomes. Hassan AH, et al. J Biol Chem, 2006 Jun 30. PMID 16648632

See all (106) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. a function for subunit Rtt102 as a stabilizing factor for the Arp7/9 heterodime
    Title: Subunit Rtt102 controls the conformation of the Arp7/9 heterodimer and its interactions with nucleotide and the catalytic subunit of SWI/SNF remodelers.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chromatin remodeling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in nucleosome disassembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transcription elongation by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of NuA4 histone acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of RSC-type complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of SWI/SNF complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SWI/SNF complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in intracellular non-membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Arp7p
NP_015359.1
  • Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    639525..640958
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184131.1 → NP_015359.1  TPA: Arp7p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015359.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W444, Q12406
    UniProtKB/TrEMBL
    A0A8H4BW59, A6ZWS7, B3LL95, B5VTJ2, C7GQA4, C8ZJ58, G2WPL2, N1NVJ7
    Conserved Domains (1) summary
    COG5277
    Location:1 → 471
    COG5277; Actin-related protein [Cytoskeleton]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12406.1

Gene LinkOut

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