VMA13 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: VMA13
Primary source: FungiDB:YPR036W
Locus tag: YPR036W
See related: SGD:S000006240; AllianceGenome:SGD:S000006240; VEuPathDB:YPR036W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: CLS11
Summary: Predicted to enable proton-transporting ATPase activity, rotational mechanism. Involved in vacuolar acidification. Located in fungal-type vacuole membrane. Orthologous to human ATP6V1H (ATPase H+ transporting V1 subunit H). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See VMA13 in Genome Data Viewer

Location:: chromosome: XVI

Exon count:: 1

Sequence:: Chromosome: XVI; NC_001148.4 (643836..645272)

Chromosome XVI - NC_001148.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Domain characterization and interaction of the yeast vacuolar ATPase subunit C with the peripheral stator stalk subunits E and G
Title: Domain characterization and interaction of the yeast vacuolar ATPase subunit C with the peripheral stator stalk subunits E and G.
analysis of the N-terminal domain of subunit H (Vma13p) of the yeast vacuolar ATPase
Title: Functional characterization of the N-terminal domain of subunit H (Vma13p) of the yeast vacuolar ATPase.
Subunit H of the vacuolar (H+) ATPase inhibits ATP hydrolysis by the free V1 domain by interaction with the rotary subunit F
Title: Subunit H of the vacuolar (H+) ATPase inhibits ATP hydrolysis by the free V1 domain by interaction with the rotary subunit F.
V-ATPase subunit balance has an important role in supporting vacuolar acidification and silencing cytosolic V1-ATPase activity
Title: Diploids heterozygous for a vma13Delta mutation in Saccharomyces cerevisiae highlight the importance of V-ATPase subunit balance in supporting vacuolar acidification and silencing cytosolic V1-ATPase activity.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables proton-transporting ATPase activity, rotational mechanism	IEA Inferred from Electronic Annotation more info
enables proton-transporting ATPase activity, rotational mechanism	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in vacuolar acidification	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in fungal-type vacuole membrane	HDA more info	PubMed
is_active_in fungal-type vacuole membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in fungal-type vacuole membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in vacuolar membrane	IEA Inferred from Electronic Annotation more info
part_of vacuolar proton-transporting V-type ATPase, V1 domain	IEA Inferred from Electronic Annotation more info
part_of vacuolar proton-transporting V-type ATPase, V1 domain	TAS Traceable Author Statement more info	PubMed
located_in vacuole	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: H(+)-transporting V1 sector ATPase subunit H

NP_015361.1

Subunit H of the V1 peripheral membrane domain of V-ATPase; part of the electrogenic proton pump found throughout the endomembrane system; serves as an activator or a structural stabilizer of the V-ATPase; the V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase) has eight subunits

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001148.4 Reference assembly

Range

643836..645272

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001184133.1 → NP_015361.1 TPA: H(+)-transporting V1 sector ATPase subunit H [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_015361.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W446, P41807

UniProtKB/TrEMBL

A6ZWS9, B3LL97, C7GQA2, C8ZJ60, G2WPL4, N1NWA0

Conserved Domains (1) summary

COG5231
Location:1 → 478

VMA13; Vacuolar H+-ATPase V1 sector, subunit H [Energy production and conversion]