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TIP41 Tip41p [ Saccharomyces cerevisiae S288C ]

Gene ID: 856153, updated on 29-Jun-2024

Summary

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Gene symbol
TIP41
Gene description
Tip41p
Primary source
FungiDB:YPR040W
Locus tag
YPR040W
See related
SGD:S000006244; AllianceGenome:SGD:S000006244; VEuPathDB:YPR040W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Acts upstream of or within negative regulation of TORC1 signaling. Located in cytoplasm and nucleus. Orthologous to human TIPRL (TOR signaling pathway regulator). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See TIP41 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (647305..648375)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Spo24p Neighboring gene flavin-linked sulfhydryl oxidase Neighboring gene Irc16p Neighboring gene translation initiation factor eIF5 Neighboring gene Puf2p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. TDP-43 Toxicity in Yeast Is Associated with a Reduction in Autophagy, and Deletions of TIP41 and PBP1 Counteract These Effects. Park SK, et al. Viruses, 2022 Oct 15. PMID 36298819, Free PMC Article
  2. LAS24/KOG1, a component of the TOR complex 1 (TORC1), is needed for resistance to local anesthetic tetracaine and normal distribution of actin cytoskeleton in yeast. Araki T, et al. Genes Genet Syst, 2005 Oct. PMID 16394584
  3. TORC1 controls degradation of the transcription factor Stp1, a key effector of the SPS amino-acid-sensing pathway in Saccharomyces cerevisiae. Shin CS, et al. J Cell Sci, 2009 Jun 15. PMID 19494127
  4. Normal function of the yeast TOR pathway requires the type 2C protein phosphatase Ptc1. González A, et al. Mol Cell Biol, 2009 May. PMID 19273591, Free PMC Article
  5. Tap42-associated protein phosphatase type 2A negatively regulates induction of autophagy. Yorimitsu T, et al. Autophagy, 2009 Jul. PMID 19223769, Free PMC Article

See all (58) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in TOR signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of TORC1 signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of phosphoprotein phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Tip41p
NP_015365.1
  • Tap42p-interacting protein; negative regulator of the TORC1 signaling pathway that activates the type 2A-related phosphatase Sit4p by binding and antagonizing Tap42p, a SIT4 inhibitor; proposed to be part of a feedback loop to amplify Sit4p activity when TORC1 is inactivated; protein abundance increases in response to DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    647305..648375
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184137.1 → NP_015365.1  TPA: Tip41p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015365.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W449, Q12199
    UniProtKB/TrEMBL
    A0A6A5Q5S7, A6ZWT2, B3LLA0, C7GQ99, C8ZJ65, G2WPL7, N1NVJ8
    Conserved Domains (1) summary
    pfam04176
    Location:130 → 312
    TIP41; TIP41-like family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12199.1

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