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PUF2 Puf2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 856155, updated on 2-Nov-2024

Summary

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Official Symbol
PUF2
Official Full Name
Puf2p
Primary source
SGD:S000006246
Locus tag
YPR042C
See related
AllianceGenome:SGD:S000006246; FungiDB:YPR042C; VEuPathDB:YPR042C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables mRNA binding activity. Involved in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay. Located in cytoplasm. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See PUF2 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (650435..653662, complement)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Tip41p Neighboring gene translation initiation factor eIF5 Neighboring gene ribosomal 60S subunit protein L43A Neighboring gene Thp3p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional analysis of three adjacent open reading frames from the right arm of yeast chromosome XVI. Waśkiewicz-Staniorowska B, et al. Yeast, 1998 Aug. PMID 9730282
  2. Phosphorylation of mRNA-Binding Proteins Puf1 and Puf2 by TORC2-Activated Protein Kinase Ypk1 Alleviates Their Repressive Effects. Galez HA, et al. Membranes (Basel), 2021 Jun 30. PMID 34209236, Free PMC Article
  3. Specific and modular binding code for cytosine recognition in Pumilio/FBF (PUF) RNA-binding domains. Dong S, et al. J Biol Chem, 2011 Jul 29. PMID 21653694, Free PMC Article
  4. Extensive association of functionally and cytotopically related mRNAs with Puf family RNA-binding proteins in yeast. Gerber AP, et al. PLoS Biol, 2004 Mar. PMID 15024427, Free PMC Article
  5. Multiple Puf proteins regulate the stability of ribosome biogenesis transcripts. Fischer AD, et al. RNA Biol, 2018. PMID 30251908, Free PMC Article

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA 3'-UTR AU-rich region binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA binding HDA PubMed 
enables mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables mRNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of gene expression IEA
Inferred from Electronic Annotation
more info
  
involved_in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in post-transcriptional regulation of gene expression IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of biological quality IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in P-body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Puf2p
NP_015367.1
  • PUF family mRNA-binding protein; Pumilio homology domain confers RNA binding activity; preferentially binds mRNAs encoding membrane-associated proteins; binding site composed of two UAAU tetranucleotides, separated by a 3-nt linker; PUF2 has a paralog, JSN1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    650435..653662 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184139.1 → NP_015367.1  TPA: Puf2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015367.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W451, Q02573, Q04142, Q12221, Q7LH42, Q7LH98
    UniProtKB/TrEMBL
    G2WPL9, N1NWA3
    Conserved Domains (1) summary
    COG5099
    Location:70 → 884
    COG5099; RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal structure and biogenesis]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12221.1

Gene LinkOut

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