U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

THP3 Thp3p [ Saccharomyces cerevisiae S288C ]

Gene ID: 856158, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
THP3
Official Full Name
Thp3p
Primary source
SGD:S000006249
Locus tag
YPR045C
See related
AllianceGenome:SGD:S000006249; FungiDB:YPR045C; VEuPathDB:YPR045C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in mRNA splicing, via spliceosome. Located in euchromatin. Orthologous to human LENG8 (leukocyte receptor cluster member 8). [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See THP3 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (655140..656552, complement)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Puf2p Neighboring gene ribosomal 60S subunit protein L43A Neighboring gene Mcm16p Neighboring gene phenylalanine--tRNA ligase

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Structural assembly of the nucleic-acid-binding Thp3-Csn12-Sem1 complex functioning in mRNA splicing. Kuang Z, et al. Nucleic Acids Res, 2022 Aug 26. PMID 35904806, Free PMC Article
  2. New suppressors of THO mutations identify Thp3 (Ypr045c)-Csn12 as a protein complex involved in transcription elongation. Jimeno S, et al. Mol Cell Biol, 2011 Feb. PMID 21149575, Free PMC Article
  3. Sec66-Dependent Regulation of Yeast Spindle-Pole Body Duplication Through Pom152. Katta SS, et al. Genetics, 2015 Dec. PMID 26510791, Free PMC Article
  4. A systematic genetic screen for genes involved in sensing inorganic phosphate availability in Saccharomyces cerevisiae. Choi J, et al. PLoS One, 2017. PMID 28520786, Free PMC Article
  5. Systematic yeast synthetic lethal and synthetic dosage lethal screens identify genes required for chromosome segregation. Measday V, et al. Proc Natl Acad Sci U S A, 2005 Sep 27. PMID 16172405, Free PMC Article

See all (52) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. role in transcription elongation for Ypr045c (Thp3) and the Csn12 component of the COP9 signalosome
    Title: New suppressors of THO mutations identify Thp3 (Ypr045c)-Csn12 as a protein complex involved in transcription elongation.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in mRNA splicing, via spliceosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in euchromatin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Thp3p
NP_015370.1
  • Protein that may have a role in transcription elongation; forms a complex with Csn12p that is recruited to transcribed genes; possibly involved in splicing based on pre-mRNA accumulation defect for many intron-containing genes

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    655140..656552 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184142.1 → NP_015370.1  TPA: Thp3p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015370.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W453, Q07109, Q12049
    UniProtKB/TrEMBL
    A6ZWT6, B3LLA3, C7GY34, C8ZJ70, G2WPM1, N1P239
    Conserved Domains (1) summary
    cl24019
    Location:206 → 424
    CSN8_PSD8_EIF3K; CSN8/PSMD8/EIF3K family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12049.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools