U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

TAH18 NAPDH-dependent diflavin reductase [ Saccharomyces cerevisiae S288C ]

Gene ID: 856161, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
TAH18
Official Full Name
NAPDH-dependent diflavin reductase
Primary source
SGD:S000006252
Locus tag
YPR048W
See related
AllianceGenome:SGD:S000006252; FungiDB:YPR048W; VEuPathDB:YPR048W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables oxidoreductase activity, acting on NAD(P)H. Involved in iron-sulfur cluster assembly; nitric oxide biosynthetic process; and positive regulation of nitric oxide biosynthetic process. Located in mitochondrion. Orthologous to human NDOR1 (NADPH dependent diflavin oxidoreductase 1). [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See TAH18 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (659182..661053)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Mcm16p Neighboring gene phenylalanine--tRNA ligase Neighboring gene autophagy protein ATG11 Neighboring gene peptide alpha-N-acetyltransferase MAK3

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Interaction between the reductase Tah18 and highly conserved Fe-S containing Dre2 C-terminus is essential for yeast viability. Soler N, et al. Mol Microbiol, 2011 Oct. PMID 21902732
  2. Regulatory mechanism of the flavoprotein Tah18-dependent nitric oxide synthesis and cell death in yeast. Yoshikawa Y, et al. Nitric Oxide, 2016 Jul 1. PMID 27178802
  3. The flavoprotein Tah18-dependent NO synthesis confers high-temperature stress tolerance on yeast cells. Nishimura A, et al. Biochem Biophys Res Commun, 2013 Jan 4. PMID 23159617
  4. DNA replication inhibitor hydroxyurea alters Fe-S centers by producing reactive oxygen species in vivo. Huang ME, et al. Sci Rep, 2016 Jul 11. PMID 27405729, Free PMC Article
  5. A newly identified essential complex, Dre2-Tah18, controls mitochondria integrity and cell death after oxidative stress in yeast. Vernis L, et al. PLoS One, 2009. PMID 19194512, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Tah18-dependent NO production and cell death are suppressed by enhancement of the interaction between Tah18 and its molecular partner Dre2
    Title: Regulatory mechanism of the flavoprotein Tah18-dependent nitric oxide synthesis and cell death in yeast.
  2. the pathways for RNR and Fe-S cluster biogenesis bifurcate after the Dre2-Tah18 step.
    Title: The diferric-tyrosyl radical cluster of ribonucleotide reductase and cytosolic iron-sulfur clusters have distinct and similar biogenesis requirements.
  3. Gene knockdown analysis demonstrated that Tah18-dependent NO synthesis confers high-temperature stress tolerance on yeast cells.
    Title: The flavoprotein Tah18-dependent NO synthesis confers high-temperature stress tolerance on yeast cells.
  4. Interaction between the Tah18 and Dre2 C-terminus is essential for viability.
    Title: Interaction between the reductase Tah18 and highly conserved Fe-S containing Dre2 C-terminus is essential for yeast viability.
  5. These results are in favour of an oxidative stress-induced cell death in yeast that involves mitochondria and is controlled by the newly identified Dre2-Tah18 complex.
    Title: A newly identified essential complex, Dre2-Tah18, controls mitochondria integrity and cell death after oxidative stress in yeast.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables FMN binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables FMN binding IEA
Inferred from Electronic Annotation
more info
  
enables NADP binding IEA
Inferred from Electronic Annotation
more info
  
enables NADPH-hemoprotein reductase activity IEA
Inferred from Electronic Annotation
more info
  
enables flavin adenine dinucleotide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on NAD(P)H IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxidoreductase activity, acting on NAD(P)H IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in iron-sulfur cluster assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in iron-sulfur cluster assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nitric oxide biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of nitric oxide biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
NAPDH-dependent diflavin reductase
NP_015373.1
  • Conserved NAPDH-dependent diflavin reductase; component of an early step in the cytosolic Fe-S protein assembly (CIA) machinery; transfers electrons from NADPH to the Fe-S cluster of Dre2p; plays a pro-death role under oxidative stress; Tah18p-dependent nitric oxide synthesis confers high-temperature stress tolerance; possible target for development of antifungal drugs

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    659182..661053
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184145.1 → NP_015373.1  TPA: NAPDH-dependent diflavin reductase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015373.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W456, Q12181
    UniProtKB/TrEMBL
    A6ZWT9, B3LLA6, B5VTK2, C7GY37, C8ZJ73, N1NW17
    Conserved Domains (1) summary
    COG0369
    Location:1 → 623
    CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12181.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools