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NOT5 CCR4-NOT core subunit NOT5 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856186, updated on 2-Nov-2024

Summary

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Official Symbol
NOT5
Official Full Name
CCR4-NOT core subunit NOT5
Primary source
SGD:S000006276
Locus tag
YPR072W
See related
AllianceGenome:SGD:S000006276; FungiDB:YPR072W; VEuPathDB:YPR072W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in several processes, including nuclear-transcribed mRNA catabolic process; positive regulation of transcription elongation by RNA polymerase II; and transcription elongation by RNA polymerase II. Located in cytoplasm. Part of CCR4-NOT core complex. Orthologous to human CNOT3 (CCR4-NOT transcription complex subunit 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See NOT5 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (690107..691789)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene tRNA-Ser Neighboring gene tyrosine protein phosphatase LTP1 Neighboring gene transketolase TKL1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Not4 and Not5 modulate translation elongation by Rps7A ubiquitination, Rli1 moonlighting, and condensates that exclude eIF5A. Allen GE, et al. Cell Rep, 2021 Aug 31. PMID 34469733
  2. The yeast EDC1 mRNA undergoes deadenylation-independent decapping stimulated by Not2p, Not4p, and Not5p. Muhlrad D, et al. EMBO J, 2005 Mar 9. PMID 15706350, Free PMC Article
  3. Ccr4-not complex mRNA deadenylase activity contributes to DNA damage responses in Saccharomyces cerevisiae. Traven A, et al. Genetics, 2005 Jan. PMID 15466434, Free PMC Article
  4. Characterization of NOT5 that encodes a new component of the Not protein complex. Oberholzer U, et al. Gene, 1998 Jan 19. PMID 9511744
  5. Structure and RNA-binding properties of the Not1-Not2-Not5 module of the yeast Ccr4-Not complex. Bhaskar V, et al. Nat Struct Mol Biol, 2013 Nov. PMID 24121231

See all (92) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Not4 and Not5 modulate translation elongation by Rps7A ubiquitination, Rli1 moonlighting, and condensates that exclude eIF5A.
    Title: Not4 and Not5 modulate translation elongation by Rps7A ubiquitination, Rli1 moonlighting, and condensates that exclude eIF5A.
  2. Not5-dependent co-translational assembly of Ada2 and Spt20 is essential for functional integrity of SAGA histone acetyltransferase complexes. SAGA mRNAs encoding a core set of SAGA subunits are tethered together for co-translational assembly of the encoded proteins.
    Title: Not5-dependent co-translational assembly of Ada2 and Spt20 is essential for functional integrity of SAGA.
  3. Hence taken together our results show that Not5 interconnects translation and transcription.
    Title: The Not5 subunit of the ccr4-not complex connects transcription and translation.
  4. Not2 and Not5 have extended regions that wrap around Not1 and around their globular domains, the Not boxes.
    Title: Structure and RNA-binding properties of the Not1-Not2-Not5 module of the yeast Ccr4-Not complex.
  5. Not4 is required for appropriate association of the Not5 subunit of the Ccr4-Not complex with polysomes and for ubiquitination of Rps7A.
    Title: Presence of Not5 and ubiquitinated Rps7A in polysome fractions depends upon the Not4 E3 ligase.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in deadenylation-dependent decapping of nuclear-transcribed mRNA IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in deadenylation-independent decapping of nuclear-transcribed mRNA IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nuclear-transcribed mRNA poly(A) tail shortening IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nuclear-transcribed mRNA poly(A) tail shortening IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in nuclear-transcribed mRNA poly(A) tail shortening IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of transcription elongation by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein ubiquitination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in transcription elongation by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of CCR4-NOT core complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of CCR4-NOT core complex IEA
Inferred from Electronic Annotation
more info
  
part_of CCR4-NOT core complex IPI
Inferred from Physical Interaction
more info
 PubMed 
is_active_in P-body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
CCR4-NOT core subunit NOT5
NP_015397.1
  • Component of the CCR4-NOT core complex, involved in mRNA decapping; involved intranscription initiation and elongation and in mRNA degradation; conserved lysine in human homolog of Not5p and Not3p is mutated in cancers

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    690107..691789
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184169.1 → NP_015397.1  TPA: CCR4-NOT core subunit NOT5 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015397.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W476, Q12514
    UniProtKB/TrEMBL
    A6ZWV9, B3LLC5, B5VTL9, C7GXZ8, G2WPP4, N1P269
    Conserved Domains (1) summary
    COG5665
    Location:11 → 560
    COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12514.1

Gene LinkOut

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