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OPY2 Opy2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 856191, updated on 18-Sep-2024

Summary

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Official Symbol
OPY2
Official Full Name
Opy2p
Primary source
SGD:S000006279
Locus tag
YPR075C
See related
AllianceGenome:SGD:S000006279; FungiDB:YPR075C; VEuPathDB:YPR075C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in several processes, including mitotic cell cycle G1 arrest in response to pheromone; osmosensory signaling pathway; and positive regulation of filamentous growth of a population of unicellular organisms in response to starvation. Is integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See OPY2 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (695737..696819, complement)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene tyrosine protein phosphatase LTP1 Neighboring gene transketolase TKL1 Neighboring gene uncharacterized protein Neighboring gene Mrl1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Interaction between the transmembrane domains of Sho1 and Opy2 enhances the signaling efficiency of the Hog1 MAP kinase cascade in Saccharomyces cerevisiae. Takayama T, et al. PLoS One, 2019. PMID 30682143, Free PMC Article
  2. Binding of the Extracellular Eight-Cysteine Motif of Opy2 to the Putative Osmosensor Msb2 Is Essential for Activation of the Yeast High-Osmolarity Glycerol Pathway. Yamamoto K, et al. Mol Cell Biol, 2016 Feb 1. PMID 26598606, Free PMC Article
  3. The transmembrane protein Opy2 mediates activation of the Cek1 MAP kinase in Candida albicans. Herrero de Dios C, et al. Fungal Genet Biol, 2013 Jan. PMID 23149115
  4. Binding the atypical RA domain of Ste50p to the unfolded Opy2p cytoplasmic tail is essential for the high-osmolarity glycerol pathway. Ekiel I, et al. Mol Biol Cell, 2009 Dec. PMID 19846660, Free PMC Article
  5. Short linear motifs in intrinsically disordered regions modulate HOG signaling capacity. Strome B, et al. BMC Syst Biol, 2018 Jul 3. PMID 29970070, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Sho1-Opy2 interaction enhances the activation of Pbs2 by Ste11, but not Hog1 by Pbs2. Chemical crosslinking and mutational analyses revealed that the cytoplasmic ends of Sho1 TM1 and Opy2 TM also interact with each other, defining the Sho1-Opy2 binding site 2 (BS2).
    Title: Interaction between the transmembrane domains of Sho1 and Opy2 enhances the signaling efficiency of the Hog1 MAP kinase cascade in Saccharomyces cerevisiae.
  2. The extracellular cysteine-rich domain of the transmembrane-anchor protein Opy2 binds to the Hkr1-Msb2 homology domain of the putative osmosensor Msb2 and the formation of the Opy2-Msb2 complex is essential for osmotic activation of Hog1.
    Title: Binding of the Extracellular Eight-Cysteine Motif of Opy2 to the Putative Osmosensor Msb2 Is Essential for Activation of the Yeast High-Osmolarity Glycerol Pathway.
  3. Dynamic regulation of Ste50-Opy2 interaction fine-tunes the MAPK signaling network.
    Title: Dynamic control of yeast MAP kinase network by induced association and dissociation between the Ste50 scaffold and the Opy2 membrane anchor.
  4. Two peptide motifs within the intrinsically disordered cytoplasmic tail of Opy2p physically interact with the Step50p-RA domain.
    Title: Binding the atypical RA domain of Ste50p to the unfolded Opy2p cytoplasmic tail is essential for the high-osmolarity glycerol pathway.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in mitotic cell cycle G1 arrest in response to pheromone IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in osmosensory signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in osmosensory signaling pathway IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in positive regulation of filamentous growth of a population of unicellular organisms in response to starvation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to plasma membrane IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in endoplasmic reticulum HDA PubMed 
located_in fungal-type vacuole HDA PubMed 
located_in fungal-type vacuole membrane HDA PubMed 
located_in plasma membrane HDA PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in vacuolar membrane IEA
Inferred from Electronic Annotation
more info
  
located_in vacuole IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Opy2p
NP_015400.1
  • Integral membrane protein that acts as a membrane anchor for Ste50p; involved in the signaling branch of the high-osmolarity glycerol (HOG) pathway and as a regulator of the filamentous growth pathway; overproduction blocks cell cycle arrest in the presence of mating pheromone; relocalizes from vacuole to plasma membrane upon DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    695737..696819 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184172.1 → NP_015400.1  TPA: Opy2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015400.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W479, Q06810, Q6B149
    UniProtKB/TrEMBL
    B3LLC7, B5VTM2, N1NW28
    Conserved Domains (1) summary
    pfam09463
    Location:30 → 63
    Opy2; Opy2 protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q06810.1

Gene LinkOut

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