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SRP54 RNA-binding signal recognition particle subunit SRP54 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856203, updated on 28-Oct-2024

Summary

Official Symbol
SRP54
Official Full Name
RNA-binding signal recognition particle subunit SRP54
Primary source
SGD:S000006292
Locus tag
YPR088C
See related
AllianceGenome:SGD:S000006292; FungiDB:YPR088C; VEuPathDB:YPR088C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
SRH1
Summary
Enables 7S RNA binding activity. Involved in SRP-dependent cotranslational protein targeting to membrane. Located in endoplasmic reticulum. Part of signal recognition particle, endoplasmic reticulum targeting. Used to study severe congenital neutropenia 8. Human ortholog(s) of this gene implicated in severe congenital neutropenia 8. Orthologous to human SRP54 (signal recognition particle 54). [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

See SRP54 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (711403..713028, complement)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Asa1p Neighboring gene transcription factor TFIIB Neighboring gene uncharacterized protein Neighboring gene Nvj2p

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables 7S RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables 7S RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables 7S RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 
contributes_to GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables endoplasmic reticulum signal peptide binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
part_of signal recognition particle IEA
Inferred from Electronic Annotation
more info
 
part_of signal recognition particle, endoplasmic reticulum targeting IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of signal recognition particle, endoplasmic reticulum targeting IDA
Inferred from Direct Assay
more info
PubMed 
part_of signal recognition particle, endoplasmic reticulum targeting IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
RNA-binding signal recognition particle subunit SRP54
NP_015413.1
  • Signal recognition particle (SRP) subunit (homolog of mammalian SRP54); contains the signal sequence-binding activity of SRP, interacts with the SRP RNA, and mediates binding of SRP to signal receptor; contains GTPase domain

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    711403..713028 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184185.1NP_015413.1  TPA: RNA-binding signal recognition particle subunit SRP54 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015413.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W489, P20424
    UniProtKB/TrEMBL
    A6ZWX2, B5VTN4, C7GPT0, C8ZJB2, G2WPQ7, N1NW32
    Conserved Domains (2) summary
    TIGR01425
    Location:2436
    SRP54_euk; signal recognition particle protein SRP54
    pfam07271
    Location:431484
    Cytadhesin_P30; Cytadhesin P30/P32