FHL1 Fhl1p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: FHL1
Official Full Name: Fhl1p
Primary source: SGD:S000006308
Locus tag: YPR104C
See related: AllianceGenome:SGD:S000006308; FungiDB:YPR104C; VEuPathDB:YPR104C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: SPP42
Summary: Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; transcription coactivator binding activity; and transcription corepressor binding activity. Involved in negative regulation of ribosomal protein gene transcription by RNA polymerase II and positive regulation of ribosomal protein gene transcription by RNA polymerase II. Located in chromatin and nucleolus. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See FHL1 in Genome Data Viewer

Location:: chromosome: XVI

Exon count:: 1

Sequence:: Chromosome: XVI; NC_001148.4 (733623..736433, complement)

Chromosome XVI - NC_001148.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Physiological function of FKBP12, a primary target of rapamycin/FK506: a newly identified role in transcription of ribosomal protein genes in yeast.
Title: Physiological function of FKBP12, a primary target of rapamycin/FK506: a newly identified role in transcription of ribosomal protein genes in yeast.
Increased RNA production in Saccharomyces cerevisiae by simultaneously overexpressing FHL1, IFH1, and SSF2 and deleting HRP1.
Title: Increased RNA production in Saccharomyces cerevisiae by simultaneously overexpressing FHL1, IFH1, and SSF2 and deleting HRP1.
Fhl1p regulates RNR1 gene transcription to maintain dNTP levels, thus modulating longevity by protection against replication stress
Title: The forkhead-like transcription factor (Fhl1p) maintains yeast replicative lifespan by regulating ribonucleotide reductase 1 (RNR1) gene transcription.
Heterozygous diploid knockout strains for FHL1, RAP1, REB1, and MCM1 genes showed significantly short lifespan.
Title: Transcription factor genes essential for cell proliferation and replicative lifespan in budding yeast.
The HMO1 promoter is regulated by TOR signaling through an HMO1- and Fhl1-dependent mechanism.
Title: Expression of yeast high mobility group protein HMO1 is regulated by TOR signaling.
Fhl1p and Ifh1p are key players in the transcription of ribosomal protein genes
Title: Central role of Ifh1p-Fhl1p interaction in the synthesis of yeast ribosomal proteins.
FHL1 is involved in the target of rapamycin (TOR)-protein kinase A regulated transcription of Ribosomal protein gene in yeast.
Title: TOR regulates ribosomal protein gene expression via PKA and the Forkhead transcription factor FHL1.
the interaction between Fhl1p and Ifh1p is critical for the regulation of CPC2 transcription during utilization of different carbon sources.
Title: The yeast CPC2/ASC1 gene is regulated by the transcription factors Fhl1p and Ifh1p.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	HDA more info	PubMed
enables sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables transcription coactivator binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription corepressor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of ribosomal protein gene transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of ribosomal protein gene transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ribosomal protein gene transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of ribosomal protein gene transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of ribosomal protein gene transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Fhl1p

NP_015429.1

Regulator of ribosomal protein (RP) transcription; has forkhead associated domain that binds phosphorylated proteins; recruits coactivator Ifh1p or corepressor Crf1p to RP gene promoters; also has forkhead DNA-binding domain though in vitro DNA binding assays give inconsistent results; computational analyses suggest it binds DNA directly at highly active RP genes and indirectly through Rap1p motifs at others; suppresses RNA pol III and splicing factor prp4 mutants

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001148.4 Reference assembly

Range

733623..736433 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001184201.1 → NP_015429.1 TPA: Fhl1p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_015429.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W4A2, P39521

UniProtKB/TrEMBL

A6ZWY4, B3LK68, C8ZJC6

Conserved Domains (1) summary

COG5025
Location:18 → 739

COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]