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RPN7 proteasome regulatory particle lid subunit RPN7 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856223, updated on 2-Nov-2024

Summary

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Official Symbol
RPN7
Official Full Name
proteasome regulatory particle lid subunit RPN7
Primary source
SGD:S000006312
Locus tag
YPR108W
See related
AllianceGenome:SGD:S000006312; FungiDB:YPR108W; VEuPathDB:YPR108W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables structural molecule activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Located in nucleus. Part of proteasome regulatory particle, lid subcomplex. Orthologous to human PSMD6 (proteasome 26S subunit, non-ATPase 6). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See RPN7 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (742454..743743)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene putative protein kinase ISR1 Neighboring gene cleavage polyadenylation factor RNA-binding subunit YTH1 Neighboring gene tRNA-Thr Neighboring gene Gld1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The assembly pathway of the 19S regulatory particle of the yeast 26S proteasome. Isono E, et al. Mol Biol Cell, 2007 Feb. PMID 17135287, Free PMC Article
  2. Expanded Coverage of the 26S Proteasome Conformational Landscape Reveals Mechanisms of Peptidase Gating. Eisele MR, et al. Cell Rep, 2018 Jul 31. PMID 30067984, Free PMC Article
  3. Localization of the regulatory particle subunit Sem1 in the 26S proteasome. Bohn S, et al. Biochem Biophys Res Commun, 2013 May 31. PMID 23643786
  4. Rpn7 Is required for the structural integrity of the 26 S proteasome of Saccharomyces cerevisiae. Isono E, et al. J Biol Chem, 2004 Jun 25. PMID 15102831
  5. Unified nomenclature for subunits of the Saccharomyces cerevisiae proteasome regulatory particle. Finley D, et al. Trends Biochem Sci, 1998 Jul. PMID 9697412

See all (123) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables structural molecule activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of proteasome complex IEA
Inferred from Electronic Annotation
more info
  
part_of proteasome regulatory particle IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of proteasome regulatory particle, lid subcomplex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of proteasome regulatory particle, lid subcomplex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
proteasome regulatory particle lid subunit RPN7
NP_015433.1
  • Essential non-ATPase regulatory subunit of the 26S proteasome; similar to another S. cerevisiae regulatory subunit, Rpn5p, as well as to mammalian proteasome subunits

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    742454..743743
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184205.1 → NP_015433.1  TPA: proteasome regulatory particle lid subunit RPN7 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015433.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W4A6, E9P8W9, Q06103
    UniProtKB/TrEMBL
    A6ZWY8, B3LK72, B5VTP8, C7GXR9, C8ZJC9, N1NVL0
    Conserved Domains (1) summary
    COG5187
    Location:2 → 429
    RPN7; 26S proteasome regulatory complex component, contains PCI domain [Posttranslational modification, protein turnover, chaperones]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q06103.3

Gene LinkOut

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