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RPC40 DNA-directed RNA polymerase core subunit RPC40 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856226, updated on 2-Nov-2024

Summary

Official Symbol
RPC40
Official Full Name
DNA-directed RNA polymerase core subunit RPC40
Primary source
SGD:S000006314
Locus tag
YPR110C
See related
AllianceGenome:SGD:S000006314; FungiDB:YPR110C; VEuPathDB:YPR110C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
RPC5
Summary
Contributes to RNA polymerase I activity and RNA polymerase III activity. Involved in tRNA transcription by RNA polymerase III and transcription by RNA polymerase I. Part of RNA polymerase I complex and RNA polymerase III complex. Used to study Treacher Collins syndrome 2 and hypomyelinating leukodystrophy. Human ortholog(s) of this gene implicated in Treacher Collins syndrome 3 and hypomyelinating leukodystrophy 11. Orthologous to human POLR1C (RNA polymerase I and III subunit C). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

See RPC40 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (745828..746835, complement)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene tRNA-Thr Neighboring gene Gld1p Neighboring gene serine/threonine-protein kinase DBF20 Neighboring gene RNA-binding ribosome biosynthesis protein MRD1

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to RNA polymerase I activity IBA
Inferred from Biological aspect of Ancestor
more info
 
contributes_to RNA polymerase I activity IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA polymerase I activity IEA
Inferred from Electronic Annotation
more info
 
contributes_to RNA polymerase III activity IBA
Inferred from Biological aspect of Ancestor
more info
 
contributes_to RNA polymerase III activity IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA polymerase III activity IEA
Inferred from Electronic Annotation
more info
 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in tRNA transcription by RNA polymerase III IDA
Inferred from Direct Assay
more info
PubMed 
involved_in transcription by RNA polymerase I IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of DNA-directed RNA polymerase complex IEA
Inferred from Electronic Annotation
more info
 
part_of RNA polymerase I complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of RNA polymerase I complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of RNA polymerase III complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of RNA polymerase III complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of nuclear DNA-directed RNA polymerase complex IEA
Inferred from Electronic Annotation
more info
 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
DNA-directed RNA polymerase core subunit RPC40
NP_015435.1
  • RNA polymerase subunit AC40; common to RNA polymerase I and III; predominant determinant targeting Ty1 integration upstream of Pol III-transcribed genes

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    745828..746835 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184207.1NP_015435.1  TPA: DNA-directed RNA polymerase core subunit RPC40 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015435.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W4A9, P07703
    UniProtKB/TrEMBL
    A6ZWZ1, B3LK74, B5VTQ0, C7GXS2, C8ZJD2, G2WPS7, N1NWG0
    Conserved Domains (1) summary
    cd07032
    Location:40330
    RNAP_I_II_AC40; AC40 subunit of Eukaryotic RNA polymerase (RNAP) I and RNAP III