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uncharacterized protein [ Saccharomyces cerevisiae S288C ]

Gene ID: 856230, updated on 2-Nov-2024

Summary

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Official Full Name
uncharacterized protein
Primary source
SGD:S000006318
Locus tag
YPR114W
See related
AllianceGenome:SGD:S000006318; FungiDB:YPR114W; VEuPathDB:YPR114W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to be involved in lipid homeostasis. Located in endoplasmic reticulum. Orthologous to human TLCD4 (TLC domain containing 4). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (753301..754248)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene RNA-binding ribosome biosynthesis protein MRD1 Neighboring gene CDP-diacylglycerol--inositol 3-phosphatidyltransferase Neighboring gene Rgc1p Neighboring gene Rrg8p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functions of Ceramide Synthase Paralogs YPR114w and YJR116w of Saccharomyces cerevisiae. Mallela SK, et al. PLoS One, 2016. PMID 26752183, Free PMC Article
  2. Checkpoint kinase interaction with DNA polymerase alpha regulates replication progression during stress. Hadjicharalambous A, et al. Wellcome Open Res, 2023. PMID 37766847, Free PMC Article
  3. A conserved endoplasmic reticulum membrane protein complex (EMC) facilitates phospholipid transfer from the ER to mitochondria. Lahiri S, et al. PLoS Biol, 2014 Oct. PMID 25313861, Free PMC Article
  4. Recruitment of Cytosolic J-Proteins by TOM Receptors Promotes Mitochondrial Protein Biogenesis. Opaliński Ł, et al. Cell Rep, 2018 Nov 20. PMID 30463002, Free PMC Article
  5. Effect of Sec61 interaction with Mpd1 on endoplasmic reticulum-associated degradation. Pereira F, et al. PLoS One, 2019. PMID 30682149, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Both yjr116w and ypr114w deleted mutants have fragmented vacuoles and produce less reactive oxygen species than wild type.
    Title: Functions of Ceramide Synthase Paralogs YPR114w and YJR116w of Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in lipid homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
uncharacterized protein
NP_015439.1
  • Protein distantly similar to ceramide synthases, Lag1p and Lac1p; mutation confers sensitivity to inhibitors of sphingolipid biosynthesis

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    753301..754248
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184211.1 → NP_015439.1  TPA: uncharacterized protein YPR114W [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015439.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W4B3, Q06107
    UniProtKB/TrEMBL
    C7GXS6, N1P2B4
    Conserved Domains (1) summary
    smart00724
    Location:98 → 302
    TLC; TRAM, LAG1 and CLN8 homology domains
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q06107.1

Gene LinkOut

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