U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

RRP9 Rrp9p [ Saccharomyces cerevisiae S288C ]

Gene ID: 856255, updated on 7-Jul-2024

Summary

Go to the top of the page Help
Gene symbol
RRP9
Gene description
Rrp9p
Primary source
FungiDB:YPR137W
Locus tag
YPR137W
See related
SGD:S000006341; AllianceGenome:SGD:S000006341; VEuPathDB:YPR137W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables U3 snoRNA binding activity. Involved in endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); and endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Located in nucleolus. Part of box C/D RNP complex and small-subunit processome. Orthologous to human RRP9 (ribosomal RNA processing 9, U3 small nucleolar RNA binding protein). [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See RRP9 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (802359..804080)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Mss18p Neighboring gene chromatin-binding protein CTF4 Neighboring gene gag-pol fusion protein Neighboring gene gag protein Neighboring gene tRNA-Asn

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Yeast Rrp9p is an evolutionarily conserved U3 snoRNP protein essential for early pre-rRNA processing cleavages and requires box C for its association. Venema J, et al. RNA, 2000 Nov. PMID 11105764, Free PMC Article
  2. Structural and functional analysis of the U3 snoRNA binding protein Rrp9. Zhang L, et al. RNA, 2013 May. PMID 23509373, Free PMC Article
  3. Functional gene expression profiling in yeast implicates translational dysfunction in mutant huntingtin toxicity. Tauber E, et al. J Biol Chem, 2011 Jan 7. PMID 21044956, Free PMC Article
  4. Analysis of sequence and structural features that identify the B/C motif of U3 small nucleolar RNA as the recognition site for the Snu13p-Rrp9p protein pair. Cléry A, et al. Mol Cell Biol, 2007 Feb. PMID 17145781, Free PMC Article
  5. Implication of the box C/D snoRNP assembly factor Rsa1p in U3 snoRNP assembly. Rothé B, et al. Nucleic Acids Res, 2017 Jul 7. PMID 28505348, Free PMC Article

See all (58) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Study etermined the functional interactions between Rrp9, other SSU-processome components and the 5'-terminal region of U3 in yeast pre-rRNA processing. The results identified a crucial amino acid at the surface of the Rrp9 beta-propeller, a protein-protein interaction network and roles for key segments of the U3 5'-terminal region.
    Title: Synergistic defects in pre-rRNA processing from mutations in the U3-specific protein Rrp9 and U3 snoRNA.
  2. conserved 7bc loop is crucial for specific recognition of U3, nucleolar localization of Rrp9, and yeast growth. N-terminal region of Rrp9 contains a bipartite nuclear localization signal that is dispensable for nucleolar localization.
    Title: Structural and functional analysis of the U3 snoRNA binding protein Rrp9.
  3. Sequence and structure requirements for efficient association of Rrp9p on the B/C motif were studied in yeast cells by expression of variant U3 snoRNAs and immunoselection assays.
    Title: Analysis of sequence and structural features that identify the B/C motif of U3 small nucleolar RNA as the recognition site for the Snu13p-Rrp9p protein pair.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables U3 snoRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables U3 snoRNA binding IEA
Inferred from Electronic Annotation
more info
  
enables snoRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of 90S preribosome HDA PubMed 
part_of box C/D methylation guide snoRNP complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
part_of small-subunit processome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of small-subunit processome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
Rrp9p
NP_015463.1
  • Protein involved in pre-rRNA processing; associated with U3 snRNP; component of small ribosomal subunit (SSU) processome; ortholog of the human U3-55k protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    802359..804080
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184234.1 → NP_015463.1  TPA: Rrp9p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015463.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W4D3, Q06506
    UniProtKB/TrEMBL
    A0A8H4BU80, A6ZX14, B3LK98, B5VTS4, C7GLJ7, C8ZJG0, N1NXT2
    Conserved Domains (2) summary
    sd00039
    Location:239 → 278
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:233 → 500
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q06506.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools
Miscellaneous