TIF3 Tif3p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: TIF3
Official Full Name: Tif3p
Primary source: SGD:S000006367
Locus tag: YPR163C
See related: AllianceGenome:SGD:S000006367; FungiDB:YPR163C; VEuPathDB:YPR163C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: RBL3; STM1
Summary: Enables RNA strand annealing activity; RNA strand-exchange activity; and ribosomal small subunit binding activity. Involved in cellular protein-containing complex assembly; positive regulation of ATPase activity; and regulation of RNA helicase activity. Located in cytoplasmic stress granule. Orthologous to human EIF4B (eukaryotic translation initiation factor 4B). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See TIF3 in Genome Data Viewer

Location:: chromosome: XVI

Exon count:: 1

Sequence:: Chromosome: XVI; NC_001148.4 (868645..869955, complement)

Chromosome XVI - NC_001148.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results provide a comprehensive description of the critical sequence elements in yeIF4B that support eIF4F function in mRNA recruitment by the PIC.
Title: Identification and characterization of functionally critical, conserved motifs in the internal repeats and N-terminal domain of yeast translation initiation factor 4B (yeIF4B).
The 7-repeats and an N-terminal domain of yeIF4B (NTD) are the most critical domains, which mediate binding of yeIF4B to the head of the 40S ribosomal subunit via interaction with Rps20.
Title: Yeast eIF4B binds to the head of the 40S ribosomal subunit and promotes mRNA recruitment through its N-terminal and internal repeat domains.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA strand annealing activity	IDA Inferred from Direct Assay more info	PubMed
enables RNA strand-exchange activity	IDA Inferred from Direct Assay more info	PubMed
enables mRNA binding	HDA more info	PubMed
enables ribosomal small subunit binding	IDA Inferred from Direct Assay more info	PubMed
enables single-stranded RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables translation initiation factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cytoplasmic translation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in eukaryotic translation initiation factor 4F complex assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in eukaryotic translation initiation factor 4F complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in formation of translation preinitiation complex	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in translation	IEA Inferred from Electronic Annotation more info
involved_in translational initiation	IDA Inferred from Direct Assay more info	PubMed
involved_in translational initiation	IEA Inferred from Electronic Annotation more info
involved_in translational initiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in translational initiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic stress granule	HDA more info	PubMed

General protein information

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Preferred Names: Tif3p

NP_015489.1

Translation initiation factor eIF-4B; RNA recognition motif containing single-stranded RNA binding protein that possesses RNA annealing and strand-exchange activities; stimulates the ATPase and unwinding activities of the RNA helicase eIF4A, in a synergistic manner with eIF4G; promotes assembly of the translation initiation factor complex eIF4F and the 48S preinitiation complex; interacts with Rps20p at the head of the 40S ribosomal subunit and alters the structure of the mRNA entry channel

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001148.4 Reference assembly

Range

868645..869955 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001184260.1 → NP_015489.1 TPA: Tif3p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_015489.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W4G4, P34167

UniProtKB/TrEMBL

A6ZX39, B3LKC4, C7GP46, C8ZJI9

Conserved Domains (1) summary

cd12514
Location:102 → 179

RRM4_RBM12_like; RNA recognition motif 4 (RRM4) found in RNA-binding protein RBM12, RBM12B and similar proteins