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SEC23 GTPase-activating protein SEC23 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856311, updated on 2-Nov-2024

Summary

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Official Symbol
SEC23
Official Full Name
GTPase-activating protein SEC23
Primary source
SGD:S000006385
Locus tag
YPR181C
See related
AllianceGenome:SGD:S000006385; FungiDB:YPR181C; VEuPathDB:YPR181C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables GTPase activator activity. Involved in regulation of COPII vesicle coating and reticulophagy. Located in endoplasmic reticulum. Part of COPII vesicle coat. Used to study Roberts syndrome; congenital dyserythropoietic anemia type II; and craniolenticulosutural dysplasia. Human ortholog(s) of this gene implicated in Cowden syndrome 7; congenital dyserythropoietic anemia type II; and craniolenticulosutural dysplasia. Orthologous to several human genes including SEC23B (SEC23 homolog B, COPII coat complex component). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See SEC23 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (897361..899667, complement)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Hda3p Neighboring gene E1 ubiquitin-activating protein AOS1 Neighboring gene mRNA splicing protein SMX3 Neighboring gene dolichyl-phosphate beta-D-mannosyltransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Multiple lipid transport pathways to the plasma membrane in yeast. Schnabl M, et al. Biochim Biophys Acta, 2005 Feb 21. PMID 15708361
  2. Requirement for a GTPase-activating protein in vesicle budding from the endoplasmic reticulum. Yoshihisa T, et al. Science, 1993 Mar 5. PMID 8451644
  3. A monoallelic SEC23A variant E599K associated with cranio-lenticulo-sutural dysplasia. Cisarova K, et al. Am J Med Genet A, 2022 Jan. PMID 34580982, Free PMC Article
  4. Yeast Sec23p acts in the cytoplasm to promote protein transport from the endoplasmic reticulum to the Golgi complex in vivo and in vitro. Hicke L, et al. EMBO J, 1989 Jun. PMID 2670558, Free PMC Article
  5. Yeast SEC16 gene encodes a multidomain vesicle coat protein that interacts with Sec23p. Espenshade P, et al. J Cell Biol, 1995 Oct. PMID 7593161, Free PMC Article

See all (180) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ubiquitylation of Sec23 is controlled by the Rsp5 ubiquitin ligase. Cdc48 controls the proteasome-mediated degradation of Sec23.
    Title: The Rsp5 ubiquitin ligase and the AAA-ATPase Cdc48 control the ubiquitin-mediated degradation of the COPII component Sec23.
  2. the binding of TRAPPI to Sec23 marks a coated vesicle for fusion with another COPII vesicle or the Golgi apparatus
    Title: TRAPPI tethers COPII vesicles by binding the coat subunit Sec23.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in COPII-coated vesicle budding IEA
Inferred from Electronic Annotation
more info
  
involved_in COPII-coated vesicle cargo loading IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in macroautophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of COPII vesicle coating IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in reticulophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of COPII vesicle coat IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of COPII vesicle coat IDA
Inferred from Direct Assay
more info
 PubMed 
part_of COPII vesicle coat IEA
Inferred from Electronic Annotation
more info
  
located_in ER to Golgi transport vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum exit site IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
GTPase-activating protein SEC23
NP_015507.1
  • GTPase-activating protein, stimulates the GTPase activity of Sar1p; component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat, involved in ER to Golgi transport; substrate of Ubp3/Bre5 complex; ubiquitylated by Ub-ligase Rsp5p; proteasome-mediated degradation of Sec23p is regulated by Cdc48p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    897361..899667 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184278.1 → NP_015507.1  TPA: GTPase-activating protein SEC23 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015507.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W4I1, P15303
    UniProtKB/TrEMBL
    A6ZX55, B3LKE0, B5VTW2, C7GP63, C8ZJL0, G2WPZ2, N1NWK6
    Conserved Domains (1) summary
    COG5047
    Location:1 → 767
    SEC23; Vesicle coat complex COPII, subunit SEC23 [Intracellular trafficking and secretion]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P15303.1

Gene LinkOut

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