SKI3 SKI complex subunit tetratricopeptide repeat protein SKI3 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: SKI3
Official Full Name: SKI complex subunit tetratricopeptide repeat protein SKI3
Primary source: SGD:S000006393
Locus tag: YPR189W
See related: AllianceGenome:SGD:S000006393; FungiDB:YPR189W; VEuPathDB:YPR189W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: SKI5
Summary: Involved in nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay and nuclear-transcribed mRNA catabolic process, non-stop decay. Part of Ski complex. Used to study trichohepatoenteric syndrome 1. Human ortholog(s) of this gene implicated in trichohepatoenteric syndrome 1. Orthologous to human TTC37 (tetratricopeptide repeat domain 37). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See SKI3 in Genome Data Viewer

Location:: chromosome: XVI

Exon count:: 1

Sequence:: Chromosome: XVI; NC_001148.4 (912664..916962)

Chromosome XVI - NC_001148.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ski2, Ski3, and Ski8 assemble in a tetramer with 1:1:2 stoichiometry; 370 kDa core complex shows that Ski3 forms an array of 33 tetratricopeptide repeat motifs organized in N-terminal and C-terminal arms. The C-terminal arm of Ski3 and the two Ski8 subunits position the helicase core of Ski2 centrally within the complex, enhancing RNA binding.
Title: The yeast ski complex: crystal structure and RNA channeling to the exosome complex.
Ski3p serves as a scaffold protein with its C terminus interacting with Ski8p, and the sub-C terminus interacting with Ski2p.
Title: Domain interactions within the Ski2/3/8 complex and between the Ski complex and Ski7p.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in RNA catabolic process	IEA Inferred from Electronic Annotation more info
involved_in defense response to virus	IEA Inferred from Electronic Annotation more info
involved_in nuclear-transcribed mRNA catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in nuclear-transcribed mRNA catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay	IGI Inferred from Genetic Interaction more info	PubMed
involved_in nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nuclear-transcribed mRNA catabolic process, non-stop decay	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Ski complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Ski complex	IDA Inferred from Direct Assay more info	PubMed
part_of Ski complex	IEA Inferred from Electronic Annotation more info
part_of Ski complex	IPI Inferred from Physical Interaction more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: SKI complex subunit tetratricopeptide repeat protein SKI3

NP_015515.1

Ski complex component and TPR protein; mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay; role in preventing L-A mycovirus pathogenesis; mutations in the human ortholog, TTC37, causes Syndromic diarrhea/Trichohepatoenteric (SD/THE) syndrome

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001148.4 Reference assembly

Range

912664..916962

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001184286.1 → NP_015515.1 TPA: SKI complex subunit tetratricopeptide repeat protein SKI3 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_015515.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P17883, Q06585

UniProtKB/TrEMBL

A6ZX63, B3LKE8, C7GP70, C8ZJL8

Conserved Domains (3) summary

TIGR02917
Location:412 → 836

PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein

sd00006
Location:735 → 765

TPR; TPR repeat [structural motif]

pfam18833
Location:151 → 241

TPR_22; Tetratricopeptide repeat