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ARR1 Arr1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 856329, updated on 14-Nov-2024

Summary

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Official Symbol
ARR1
Official Full Name
Arr1p
Primary source
SGD:S000006403
Locus tag
YPR199C
See related
AllianceGenome:SGD:S000006403; FungiDB:YPR199C; VEuPathDB:YPR199C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
ACR1; YAP8
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in cellular response to arsenic-containing substance and positive regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ARR1 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (938148..939032, complement)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene putative maltose-responsive transcription factor Neighboring gene Sge1p Neighboring gene Arr2p Neighboring gene Arr3p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The ancillary N-terminal region of the yeast AP-1 transcription factor Yap8 contributes to its DNA binding specificity. Maciaszczyk-Dziubinska E, et al. Nucleic Acids Res, 2020 Jun 4. PMID 32356892, Free PMC Article
  2. Two residues in the basic region of the yeast transcription factor Yap8 are crucial for its DNA-binding specificity. Amaral C, et al. PLoS One, 2013. PMID 24358276, Free PMC Article
  3. Arsenic Directly Binds to and Activates the Yeast AP-1-Like Transcription Factor Yap8. Kumar NV, et al. Mol Cell Biol, 2015 Dec 28. PMID 26711267, Free PMC Article
  4. Yap8p activation in Saccharomyces cerevisiae under arsenic conditions. Menezes RA, et al. FEBS Lett, 2004 May 21. PMID 15147884
  5. One Hand Clapping: detection of condition-specific transcription factor interactions from genome-wide gene activity data. Dümcke S, et al. Nucleic Acids Res, 2012 Oct. PMID 22844089, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The N-terminal tail of Yap8 directly interacts with DNA and stabilizes Yap8 binding to the 13 bp motif.
    Title: The ancillary N-terminal region of the yeast AP-1 transcription factor Yap8 contributes to its DNA binding specificity.
  2. As(III) binding to Yap8 acts as a molecular switch that converts inactive Yap8 into an active transcriptional regulator.
    Title: Arsenic Directly Binds to and Activates the Yeast AP-1-Like Transcription Factor Yap8.
  3. Leu26 is required for Yap8 binding to DNA and that this residue together with Asn31, hinder Yap1 response element recognition by Yap8, thus narrowing its DNA-binding specificity.
    Title: Two residues in the basic region of the yeast transcription factor Yap8 are crucial for its DNA-binding specificity.
  4. Yap8p requires distinct DNA-binding motifs to induce gene expression and propose that this fact contributed towards a separation of function between AP-1 proteins during evolution
    Title: Characterization of the DNA-binding motif of the arsenic-responsive transcription factor Yap8p.
  5. ARR1 is degraded by the ubiquitin-proteasome pathway in untreated cells, whereas arsenite-exposure results in its stabilization and gene activation.
    Title: Regulation of the arsenic-responsive transcription factor Yap8p involves the ubiquitin-proteasome pathway.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription cis-regulatory region binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription cis-regulatory region binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular response to arsenic-containing substance HMP PubMed 
involved_in cellular response to arsenic-containing substance IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cellular response to arsenic-containing substance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II HMP PubMed 
involved_in positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in response to arsenic-containing substance IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Arr1p
NP_015525.1
  • Transcriptional activator of the basic leucine zipper (bZIP) family; required for transcription of genes involved in resistance to arsenic compounds; directly binds trivalent arsenic (As(III)) as does K. lactis ortholog, KIYAP8

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    938148..939032 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184296.1 → NP_015525.1  TPA: Arr1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015525.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W4J7, Q06596
    UniProtKB/TrEMBL
    B3LRH9, B5VTX6, C8ZJM8, N1NVM8
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q06596.1

Gene LinkOut

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