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ARN1 siderophore transporter [ Saccharomyces cerevisiae S288C ]

Gene ID: 856345, updated on 2-Nov-2024

Summary

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Official Symbol
ARN1
Official Full Name
siderophore transporter
Primary source
SGD:S000001032
Locus tag
YHL040C
See related
AllianceGenome:SGD:S000001032; FungiDB:YHL040C; VEuPathDB:YHL040C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables siderophore-iron transmembrane transporter activity. Involved in siderophore transport. Located in endosome and plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ARN1 in Genome Data Viewer
Location:
chromosome: VIII
Exon count:
1
Sequence:
Chromosome: VIII; NC_001140.6 (19088..20971, complement)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene protein-lysine N-methyltransferase Neighboring gene Cbp2p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification and substrate specificity of a ferrichrome-type siderophore transporter (Arn1p) in Saccharomyces cerevisiae. Heymann P, et al. FEMS Microbiol Lett, 2000 May 15. PMID 10802175
  2. The mechanism of ferrichrome transport through Arn1p and its metabolism in Saccharomyces cerevisiae. Moore RE, et al. Proc Natl Acad Sci U S A, 2003 May 13. PMID 12721368, Free PMC Article
  3. Ferrichrome induces endosome to plasma membrane cycling of the ferrichrome transporter, Arn1p, in Saccharomyces cerevisiae. Kim Y, et al. EMBO J, 2002 Jul 15. PMID 12110576, Free PMC Article
  4. A receptor domain controls the intracellular sorting of the ferrichrome transporter, ARN1. Kim Y, et al. EMBO J, 2005 Mar 9. PMID 15719020, Free PMC Article
  5. GGA2- and ubiquitin-dependent trafficking of Arn1, the ferrichrome transporter of Saccharomyces cerevisiae. Kim Y, et al. Mol Biol Cell, 2007 May. PMID 17344478, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Phosphatidylserine is involved in the ferrichrome-induced plasma membrane trafficking of Arn1 in Saccharomyces cerevisiae
    Title: Phosphatidylserine is involved in the ferrichrome-induced plasma membrane trafficking of Arn1 in Saccharomyces cerevisiae.
  2. Ubiquitin binding by Gga2 was not required for the trans-Golgi network to endosome trafficking of Arn1, but it was required for sorting of Arn1 into the vacuole.
    Title: Gga2 mediates sequential ubiquitin-independent and ubiquitin-dependent steps in the trafficking of ARN1 from the trans-Golgi network to the vacuole.
  3. the carboxyl terminus of Arn1p contains a receptor domain that controls the intracellular trafficking of the transporter
    Title: A receptor domain controls the intracellular sorting of the ferrichrome transporter, ARN1.
  4. clathrin adaptor Gga2 and ubiquitination by the Rsp5 ubiquitin ligase are required for trafficking of Arn1
    Title: GGA2- and ubiquitin-dependent trafficking of Arn1, the ferrichrome transporter of Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables siderophore-iron transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables siderophore-iron transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in intracellular iron ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in iron ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in siderophore transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in siderophore transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in siderophore-dependent iron import into cell IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cell periphery HDA PubMed 
located_in cytoplasm HDA PubMed 
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in fungal-type vacuole HDA PubMed 
located_in nucleus HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in vacuolar membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
siderophore transporter
NP_011823.1
  • ARN family transporter for siderophore-iron chelates; responsible for uptake of iron bound to ferrirubin, ferrirhodin, and related siderophores; protein increases in abundance and relocalizes to the vacuole upon DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    19088..20971 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179120.1 → NP_011823.1  TPA: siderophore transporter [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011823.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DKS9, P38731
    UniProtKB/TrEMBL
    A6ZSL1, B3LS81, C7GRT3, G2WF26, N1P1F6
    Conserved Domains (1) summary
    cd17322
    Location:74 → 586
    MFS_ARN_like; Yeast ARN family of Siderophore iron transporters and similar proteins of the Major Facilitator Superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38731.1

Gene LinkOut

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