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EFM1 protein-lysine N-methyltransferase [ Saccharomyces cerevisiae S288C ]

Gene ID: 856346, updated on 2-Nov-2024

Summary

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Official Symbol
EFM1
Official Full Name
protein-lysine N-methyltransferase
Primary source
SGD:S000001031
Locus tag
YHL039W
See related
AllianceGenome:SGD:S000001031; FungiDB:YHL039W; VEuPathDB:YHL039W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables protein-lysine N-methyltransferase activity. Involved in peptidyl-lysine monomethylation. Located in cytoplasm. Orthologous to human SETD4 (SET domain containing 4). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See EFM1 in Genome Data Viewer
Location:
chromosome: VIII
Exon count:
1
Sequence:
Chromosome: VIII; NC_001140.6 (21783..23540)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene siderophore transporter Neighboring gene Cbp2p Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. MT-MAMS: Protein Methyltransferase Motif Analysis by Mass Spectrometry. Hamey JJ, et al. J Proteome Res, 2018 Oct 5. PMID 30156103
  2. A novel SET domain methyltransferase in yeast: Rkm2-dependent trimethylation of ribosomal protein L12ab at lysine 10. Porras-Yakushi TR, et al. J Biol Chem, 2006 Nov 24. PMID 17005568
  3. Two novel methyltransferases acting upon eukaryotic elongation factor 1A in Saccharomyces cerevisiae. Lipson RS, et al. Arch Biochem Biophys, 2010 Aug 15. PMID 20510667, Free PMC Article
  4. Methylation of translation elongation factor 1A by the METTL10-like See1 methyltransferase facilitates tombusvirus replication in yeast and plants. Li Z, et al. Virology, 2014 Jan 5. PMID 24314635
  5. Methylation of translation-associated proteins in Saccharomyces cerevisiae: Identification of methylated lysines and their methyltransferases. Couttas TA, et al. Proteomics, 2012 Apr. PMID 22522802

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-lysine N-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-lysine N-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-lysine N-methyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein-lysine N-methyltransferase activity ISA
Inferred from Sequence Alignment
more info
 PubMed 
Process Evidence Code Pubs
involved_in methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in peptidyl-lysine dimethylation IEA
Inferred from Electronic Annotation
more info
  
involved_in peptidyl-lysine monomethylation IEA
Inferred from Electronic Annotation
more info
  
involved_in peptidyl-lysine monomethylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protein-lysine N-methyltransferase
NP_011824.1
  • Lysine methyltransferase; involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    21783..23540
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179119.1 → NP_011824.1  TPA: protein-lysine N-methyltransferase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011824.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DKT0, P38732
    UniProtKB/TrEMBL
    A6ZSL2, B3LS82, C7GRT4, C8ZA24, N1P9K3
    Conserved Domains (1) summary
    cd19180
    Location:11 → 295
    SET_SpSET10-like; SET domain found in Schizosaccharomyces pombe SET domain-containing protein 10 (SETD10) and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38732.1

Gene LinkOut

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