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ETP1 Etp1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 856376, updated on 18-Sep-2024

Summary

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Official Symbol
ETP1
Official Full Name
Etp1p
Primary source
SGD:S000001002
Locus tag
YHL010C
See related
AllianceGenome:SGD:S000001002; FungiDB:YHL010C; VEuPathDB:YHL010C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables nuclear localization sequence binding activity and ubiquitin binding activity. Involved in response to ethanol. Predicted to be located in cytoplasm. Orthologous to human BRAP (BRCA1 associated protein). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See ETP1 in Genome Data Viewer
Location:
chromosome: VIII
Exon count:
1
Sequence:
Chromosome: VIII; NC_001140.6 (81964..83721, complement)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene UTP--glucose-1-phosphate uridylyltransferase Neighboring gene ribose phosphate diphosphokinase subunit PRS3 Neighboring gene Yap3p Neighboring gene tRNA-Val

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. ETP1/YHL010c is a novel gene needed for the adaptation of Saccharomyces cerevisiae to ethanol. Snowdon C, et al. FEMS Yeast Res, 2009 May. PMID 19416103
  2. The ubiquitin binding domain ZnF UBP recognizes the C-terminal diglycine motif of unanchored ubiquitin. Reyes-Turcu FE, et al. Cell, 2006 Mar 24. PMID 16564012
  3. Identification of a novel cytoplasmic protein that specifically binds to nuclear localization signal motifs. Li S, et al. J Biol Chem, 1998 Mar 13. PMID 9497340
  4. Recurrent background mutations in WHI2 impair proteostasis and degradation of misfolded cytosolic proteins in Saccharomyces cerevisiae. Comyn SA, et al. Sci Rep, 2017 Jun 23. PMID 28646136, Free PMC Article
  5. Isolation and mapping of self-assembling protein domains encoded by the Saccharomyces cerevisiae genome using lambda repressor fusions. Mariño-Ramírez L, et al. Yeast, 2002 May. PMID 11967834, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclear localization sequence binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to ethanol IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Etp1p
NP_011853.1
  • hypothetical protein required for growth on ethanol; contains a zinc finger region and has homology to human BRAP2, which is a cytoplasmic protein that binds nuclear localization sequences

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    81964..83721 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179090.1 → NP_011853.1  TPA: Etp1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011853.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DKQ3, P38748, Q6Q5F9
    UniProtKB/TrEMBL
    G2WF57
    Conserved Domains (4) summary
    COG1196
    Location:409 → 534
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd16457
    Location:238 → 281
    RING-H2_BRAP2; RING finger, H2 subclass, found in BRCA1-associated protein (BRAP2) and similar proteins
    pfam02148
    Location:301 → 363
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
    cd12717
    Location:114 → 201
    RRM_ETP1; RNA recognition motif (RRM) found in yeast RING finger protein ETP1 and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38748.1

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