U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ARD1 peptide alpha-N-acetyltransferase complex A subunit ARD1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856404, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
ARD1
Official Full Name
peptide alpha-N-acetyltransferase complex A subunit ARD1
Primary source
SGD:S000001055
Locus tag
YHR013C
See related
AllianceGenome:SGD:S000001055; FungiDB:YHR013C; VEuPathDB:YHR013C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
NAA10
Summary
Contributes to peptide alpha-N-acetyltransferase activity. Involved in N-terminal protein amino acid acetylation and N-terminal protein amino acid propionylation. Part of NatA complex. Used to study Ogden syndrome. Human ortholog(s) of this gene implicated in Ogden syndrome and syndromic microphthalmia 1. Orthologous to human NAA10 (N-alpha-acetyltransferase 10, NatA catalytic subunit) and NAA11 (N-alpha-acetyltransferase 11, NatA catalytic subunit). [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See ARD1 in Genome Data Viewer
Location:
chromosome: VIII
Exon count:
1
Sequence:
Chromosome: VIII; NC_001140.6 (130730..131446, complement)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene putative serine--tRNA ligase DIA4 Neighboring gene retromer subunit VPS29 Neighboring gene Spo13p Neighboring gene tRNA-Ser

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. A strategy for the generation of conditional mutations by protein destabilization. Park EC, et al. Proc Natl Acad Sci U S A, 1992 Feb 15. PMID 1311090, Free PMC Article
  2. N-terminal Acetylation Levels Are Maintained During Acetyl-CoA Deficiency in Saccharomyces cerevisiae. Varland S, et al. Mol Cell Proteomics, 2018 Dec. PMID 30150368, Free PMC Article
  3. The yeast ARD1 gene product is required for repression of cryptic mating-type information at the HML locus. Whiteway M, et al. Mol Cell Biol, 1987 Oct. PMID 3316986, Free PMC Article
  4. The ARD1 gene of yeast functions in the switch between the mitotic cell cycle and alternative developmental pathways. Whiteway M, et al. Cell, 1985 Dec. PMID 3907857
  5. TEL+CEN antagonism on plasmids involves telomere repeat sequences tracts and gene products that interact with chromosomal telomeres. Enomoto S, et al. Chromosoma, 1994 Jul. PMID 7988285

See all (100) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Structure and mechanism of acetylation by the N-terminal dual enzyme NatA/Naa50 complex has been reported.
    Title: Structure and Mechanism of Acetylation by the N-Terminal Dual Enzyme NatA/Naa50 Complex.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to peptide alpha-N-acetyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables peptide alpha-N-acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to peptide alpha-N-acetyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables peptide-glutamate-alpha-N-acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptide-serine-alpha-N-acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in N-terminal protein amino acid acetylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in N-terminal protein amino acid acetylation IEA
Inferred from Electronic Annotation
more info
  
involved_in N-terminal protein amino acid acetylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in N-terminal protein amino acid propionylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of NatA complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of NatA complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of NatA complex IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
peptide alpha-N-acetyltransferase complex A subunit ARD1
NP_011877.1
  • Subunit of protein N-terminal acetyltransferase NatA; NatA comprises Nat1p, Ard1p, Nat5p; acetylates many proteins to influence telomeric silencing, cell cycle, heat-shock resistance, mating, sporulation, early stages of mitophagy; protein abundance increases under DNA replication stress; mutations in human homolog X-linked NAA10 lead to Ogden syndrome (S37P) and intellectual disability (R116W); expression of human NAA10 and NAA15 can complement ard1 nat1 double mutant

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    130730..131446 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179143.1 → NP_011877.1  TPA: peptide alpha-N-acetyltransferase complex A subunit ARD1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011877.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DKV8, P07347
    UniProtKB/TrEMBL
    A6ZSR7, B3LSD4, B5VJT8, C7GMP8, C8ZA80, G2WF81, N1P9K9
    Conserved Domains (1) summary
    COG0456
    Location:1 → 192
    RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P07347.2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools