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THR1 homoserine kinase [ Saccharomyces cerevisiae S288C ]

Gene ID: 856420, updated on 29-Jun-2024

Summary

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Gene symbol
THR1
Gene description
homoserine kinase
Primary source
FungiDB:YHR025W
Locus tag
YHR025W
See related
SGD:S000001067; AllianceGenome:SGD:S000001067; VEuPathDB:YHR025W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables homoserine kinase activity. Involved in homoserine metabolic process and threonine biosynthetic process. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See THR1 in Genome Data Viewer
Location:
chromosome: VIII
Exon count:
1
Sequence:
Chromosome: VIII; NC_001140.6 (159438..160511)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene myosin 1 Neighboring gene mitochondrial-processing protease subunit alpha Neighboring gene H(+)-transporting V0 sector ATPase subunit c'' Neighboring gene proteasome regulatory particle base subunit RPN1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Saccharomyces cerevisiae homoserine kinase is homologous to prokaryotic homoserine kinases. Schultes NP, et al. Gene, 1990 Dec 15. PMID 2176637
  2. Yeast homoserine kinase. Characteristics of the corresponding gene, THR1, and the purified enzyme, and evolutionary relationships with other enzymes of threonine metabolism. Mannhaupt G, et al. Eur J Biochem, 1990 Jul 20. PMID 2165904
  3. Identification of yeast cloned genes by genetic analysis. Martín-Rendón E, et al. Microbiologia, 1992 Nov. PMID 1337256
  4. Effect of gene amplification on threonine production by yeast. Farfán MJ, et al. Biotechnol Bioeng, 1996 Mar 20. PMID 18626862
  5. Substrate specificity and identification of functional groups of homoserine kinase from Escherichia coli. Huo X, et al. Biochemistry, 1996 Dec 17. PMID 8973190

See all (81) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables homoserine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables homoserine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in homoserine metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in threonine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in threonine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in threonine metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
homoserine kinase
NP_011890.1
  • Homoserine kinase; conserved protein required for threonine biosynthesis; long-lived protein that is preferentially retained in mother cells and forms cytoplasmic filaments; expression is regulated by the GCN4-mediated general amino acid control pathway

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    159438..160511
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179155.1 → NP_011890.1  TPA: homoserine kinase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011890.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DKX2, P17423
    UniProtKB/TrEMBL
    A0A6A5PZI2, A6ZST1, B3LSE6, B5VJV5, C7GTV5, C8ZA93, G2WF96, N1P9L5
    Conserved Domains (1) summary
    TIGR00191
    Location:5 → 355
    thrB; homoserine kinase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P17423.4

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