VMA16 H(+)-transporting V0 sector ATPase subunit c'' [Saccharomyces cerevisiae S288C] - Gene

Summary

Go to the top of the page Help

Official Symbol: VMA16
Official Full Name: H(+)-transporting V0 sector ATPase subunit c''
Primary source: SGD:S000001068
Locus tag: YHR026W
See related: AllianceGenome:SGD:S000001068; FungiDB:YHR026W; VEuPathDB:YHR026W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: PPA1
Summary: Predicted to enable proton-transporting ATPase activity, rotational mechanism. Involved in vacuolar acidification. Located in membrane. Orthologous to human ATP6V0B (ATPase H+ transporting V0 subunit b). [provided by Alliance of Genome Resources, Oct 2024]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See VMA16 in Genome Data Viewer

Location:: chromosome: VIII

Exon count:: 1

Sequence:: Chromosome: VIII; NC_001140.6 (160844..161485)

Chromosome VIII - NC_001140.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Subunit c'' of the vacuolar H+-ATPase (V-ATPase) is not essential for assembly of the V-ATPase complex but is required for the functional coupling of the two domains of V-ATPase.
Title: Assembly of the yeast vacuolar H+-ATPase and ATP hydrolysis occurs in the absence of subunit c''.

Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables proton-transporting ATPase activity, rotational mechanism	IEA Inferred from Electronic Annotation more info
enables proton-transporting ATPase activity, rotational mechanism	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in vacuolar acidification	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of proton-transporting V-type ATPase, V0 domain	IEA Inferred from Electronic Annotation more info
located_in vacuolar membrane	IEA Inferred from Electronic Annotation more info
part_of vacuolar proton-transporting V-type ATPase, V0 domain	TAS Traceable Author Statement more info	PubMed
located_in vacuole	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: H(+)-transporting V0 sector ATPase subunit c''

NP_011891.1

Subunit c'' of the vacuolar ATPase; v-ATPase functions in acidification of the vacuole; one of three proteolipid subunits of the V0 domain

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001140.6 Reference assembly

Range

160844..161485

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179156.1 → NP_011891.1 TPA: H(+)-transporting V0 sector ATPase subunit c'' [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_011891.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D3DKX3, P23968

UniProtKB/TrEMBL

A6ZST2, B3LSE7, C7GTV4, C8ZA94, G2WF97, N1P387

Conserved Domains (2) summary

cd18177
Location:59 → 121

ATP-synt_Vo_c_ATP6F_rpt1; V-type proton ATPase 21 kDa proteolipid subunit (ATP6F/ATP6V0B) and similar proteins

cd18178
Location:141 → 192

ATP-synt_Vo_c_ATP6F_rpt2; V-type proton ATPase 21 kDa proteolipid subunit (ATP6F/ATP6V0B) and similar proteins