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RRM3 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856426, updated on 22-Aug-2024

Summary

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Official Symbol
RRM3
Primary source
FungiDB:YHR031C
Locus tag
YHR031C
See related
SGD:S000001073; AllianceGenome:SGD:S000001073; VEuPathDB:YHR031C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
RTT104
Summary
Enables DNA helicase activity. Involved in several processes, including G-quadruplex DNA unwinding; cellular macromolecule biosynthetic process; and replication fork progression beyond termination site. Located in nuclear replication fork. Orthologous to human PIF1 (PIF1 5'-to-3' DNA helicase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: VIII
Exon count:
1
Sequence:
Chromosome: VIII; NC_001140.6 (170799..172970, complement)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene Yhi9p Neighboring gene mitogen-activated serine/threonine-protein kinase SLT2 Neighboring gene Erc1p Neighboring gene putative glutamate 5-kinase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Stimulation of direct-repeat recombination by RNA polymerase III transcription. de la Loza MC, et al. DNA Repair (Amst), 2009 May 1. PMID 19168400
  2. Impairment of replication fork progression mediates RNA polII transcription-associated recombination. Prado F, et al. EMBO J, 2005 Mar 23. PMID 15775982, Free PMC Article
  3. Anatomy and dynamics of DNA replication fork movement in yeast telomeric regions. Makovets S, et al. Mol Cell Biol, 2004 May. PMID 15082794, Free PMC Article
  4. Saccharomyces Rrm3p, a 5' to 3' DNA helicase that promotes replication fork progression through telomeric and subtelomeric DNA. Ivessa AS, et al. Genes Dev, 2002 Jun 1. PMID 12050116, Free PMC Article
  5. Pif1-Family Helicases Support Fork Convergence during DNA Replication Termination in Eukaryotes. Deegan TD, et al. Mol Cell, 2019 Apr 18. PMID 30850330, Free PMC Article

See all (162) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The increase in cell death rates in caloric restricted cells of the yeast helicase mutant rrm3 is Sir complex dependent.
    Title: The increase in cell death rates in caloric restricted cells of the yeast helicase mutant rrm3 is Sir complex dependent.
  2. Sen1 and Rrm3 ensure permissive topological conditions for replication termination.
    Title: Sen1 and Rrm3 ensure permissive topological conditions for replication termination.
  3. Helicase activities of Rad5 and Rrm3 genetically interact in the prevention of recombinogenic DNA lesions in Saccharomyces cerevisiae.
    Title: Helicase activities of Rad5 and Rrm3 genetically interact in the prevention of recombinogenic DNA lesions in Saccharomyces cerevisiae.
  4. Pif1 family helicases promote mutation avoidance during DNA replication.
    Title: Pif1 family helicases promote mutation avoidance during DNA replication.
  5. Suppression of chromosome instability by targeting a DNA helicase in budding yeast.
    Title: Suppression of chromosome instability by targeting a DNA helicase in budding yeast.
  6. We showed that the Pif1 and Rrm3 DNA helicases promote efficient fork convergence and completion of DNA synthesis, even in the absence of type II topoisomerase. Furthermore, Rrm3 and Pif1 are also important for termination of plasmid DNA replication in vivo.
    Title: Pif1-Family Helicases Support Fork Convergence during DNA Replication Termination in Eukaryotes.
  7. The absence of Rrm3 renders cells resistant to microtubule-destabilizing drugs.
    Title: Two Pif1 Family DNA Helicases Cooperate in Centromere Replication and Segregation in Saccharomyces cerevisiae.
  8. It has been proposed that Rrm3 and Pif1 promote genome stability at tDNAs by displacing the stable multi-protein transcription complex and by removing R-loops.
    Title: PIF1 family DNA helicases suppress R-loop mediated genome instability at tRNA genes.
  9. Either Pif1 or Rrm3 redundantly stimulates strand displacement by DNA polymerase delta during lagging-strand synthesis.
    Title: Pif1-family helicases cooperatively suppress widespread replication-fork arrest at tRNA genes.
  10. Rrm3 recruitment to replication-born DSBs is crucial for viability.
    Title: A new role for Rrm3 in repair of replication-born DNA breakage by sister chromatid recombination.
Submit: New GeneRIF Correction See all GeneRIFs (22)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables 5'-3' DNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 5'-3' DNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA helicase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables G-quadruplex DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables centromeric DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in DNA duplex unwinding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in G-quadruplex DNA unwinding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in G-quadruplex DNA unwinding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrial genome maintenance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial genome maintenance IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial genome maintenance IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in replication fork progression beyond termination site IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in replication fork reversal IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in replication fork reversal IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in telomere maintenance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in telomere maintenance IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, telomeric region IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nuclear replication fork IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear replication fork IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in replication fork IDA
Inferred from Direct Assay
more info
 PubMed 
located_in replication fork IEA
Inferred from Electronic Annotation
more info
  
located_in replication fork IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
DNA helicase
NP_011896.1
  • DNA helicase involved in rDNA replication and Ty1 transposition; binds to and suppresses DNA damage at G4 motifs in vivo; relieves replication fork pauses at telomeric regions; deletion or inactivation of helicase function suppresses chromosome instability (CIN) associated with centromere or kinetochore defects; structurally and functionally related to Pif1p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    170799..172970 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179161.1 → NP_011896.1  TPA: DNA helicase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011896.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DKX8, P38766
    UniProtKB/TrEMBL
    N1P392
    Conserved Domains (2) summary
    COG0507
    Location:37 → 723
    RecD; ATP-dependent exoDNAse (exonuclease V), alpha subunit, helicase superfamily I [Replication, recombination and repair]
    cd18037
    Location:235 → 414
    DEXSc_Pif1_like; DEAD-box helicase domain of Pif1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38766.1

Gene LinkOut

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