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ERC1 Erc1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 856427, updated on 28-Oct-2024

Summary

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Official Symbol
ERC1
Official Full Name
Erc1p
Primary source
SGD:S000001074
Locus tag
YHR032W
See related
AllianceGenome:SGD:S000001074; FungiDB:YHR032W; VEuPathDB:YHR032W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable transmembrane transporter activity. Involved in S-adenosylmethionine biosynthetic process. Predicted to be active in membrane. Orthologous to human SLC47A1 (solute carrier family 47 member 1) and SLC47A2 (solute carrier family 47 member 2). [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

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See ERC1 in Genome Data Viewer
Location:
chromosome: VIII
Exon count:
1
Sequence:
Chromosome: VIII; NC_001140.6 (173344..175089)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene mitogen-activated serine/threonine-protein kinase SLT2 Neighboring gene DNA helicase Neighboring gene putative glutamate 5-kinase Neighboring gene Pih1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Production of S-adenosyl-L-methionine by Saccharomyces cerevisiae cells carrying a gene for ethionine resistance. Shiomi N, et al. Biotechnol Bioeng, 1990 May. PMID 18592490
  2. Sake yeast YHR032W/ERC1 haplotype contributes to high S-adenosylmethionine accumulation in sake yeast strains. Kanai M, et al. J Biosci Bioeng, 2017 Jan. PMID 27567046
  3. Genetic basis of metabolome variation in yeast. Breunig JS, et al. PLoS Genet, 2014 Mar. PMID 24603560, Free PMC Article
  4. Stimulating S-adenosyl-l-methionine synthesis extends lifespan via activation of AMPK. Ogawa T, et al. Proc Natl Acad Sci U S A, 2016 Oct 18. PMID 27698120, Free PMC Article
  5. An evolutionary proteomics approach identifies substrates of the cAMP-dependent protein kinase. Budovskaya YV, et al. Proc Natl Acad Sci U S A, 2005 Sep 27. PMID 16172400, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables antiporter activity IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables xenobiotic transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in S-adenosylmethionine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in xenobiotic detoxification by transmembrane export across the plasma membrane IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Erc1p
NP_011897.1
  • Member of the multi-drug and toxin extrusion (MATE) family; the MATE family is part of the multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter superfamily; overproduction confers ethionine resistance and accumulation of S-adenosylmethionine

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    173344..175089
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179162.1 → NP_011897.1  TPA: Erc1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011897.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DKX9, P38767
    UniProtKB/TrEMBL
    C8ZAA1, N1P558
    Conserved Domains (1) summary
    cd13132
    Location:164 → 544
    MATE_eukaryotic; Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38767.1

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