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NEL1 GTPase-activating protein NEL1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856430, updated on 28-Oct-2024

Summary

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Official Symbol
NEL1
Official Full Name
GTPase-activating protein NEL1
Primary source
SGD:S000001077
Locus tag
YHR035W
See related
AllianceGenome:SGD:S000001077; FungiDB:YHR035W; VEuPathDB:YHR035W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables GTPase activator activity. Predicted to be involved in COPII-coated vesicle cargo loading. Located in cytosol. [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

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See NEL1 in Genome Data Viewer
Location:
chromosome: VIII
Exon count:
1
Sequence:
Chromosome: VIII; NC_001140.6 (178219..180111)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene putative glutamate 5-kinase Neighboring gene Pih1p Neighboring gene Brl1p Neighboring gene 1-pyrroline-5-carboxylate dehydrogenase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sec23 homolog Nel1 is a novel GTPase-activating protein for Sar1 but does not function as a subunit of the coat protein complex II (COPII) coat. Kodera C, et al. J Biol Chem, 2014 Aug 1. PMID 24947508, Free PMC Article
  2. ER exit sites are physical and functional core autophagosome biogenesis components. Graef M, et al. Mol Biol Cell, 2013 Sep. PMID 23904270, Free PMC Article
  3. Toward a functional analysis of the yeast genome through exhaustive two-hybrid screens. Fromont-Racine M, et al. Nat Genet, 1997 Jul. PMID 9207794
  4. Genome-wide protein interaction screens reveal functional networks involving Sm-like proteins. Fromont-Racine M, et al. Yeast, 2000 Jun 30. PMID 10900456, Free PMC Article
  5. Comprehensive and quantitative mapping of RNA-protein interactions across a transcribed eukaryotic genome. She R, et al. Proc Natl Acad Sci U S A, 2017 Apr 4. PMID 28325876, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. demonstrated that the chromosomal deletion of NEL1 leads to a significant growth defect in the temperature-sensitive sar1D32G background, suggesting a possible functional link between these proteins
    Title: Sec23 homolog Nel1 is a novel GTPase-activating protein for Sar1 but does not function as a subunit of the coat protein complex II (COPII) coat.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in COPII-coated vesicle cargo loading IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of COPII vesicle coat IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of COPII vesicle coat IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in endoplasmic reticulum exit site IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
GTPase-activating protein NEL1
NP_011900.1
  • Activator of Sar1p GTPase activity; paralog of Sec23 but does not associate with the COPII components; not an essential gene

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    178219..180111
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179165.1 → NP_011900.1  TPA: GTPase-activating protein NEL1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011900.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DKY2, P38769
    UniProtKB/TrEMBL
    C7GTU5, G2WFA7, N1P397
    Conserved Domains (1) summary
    COG5047
    Location:1 → 630
    SEC23; Vesicle coat complex COPII, subunit SEC23 [Intracellular trafficking and secretion]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38769.1

Gene LinkOut

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