BRL1 Brl1p [Saccharomyces cerevisiae S288C] - Gene

Summary

Gene symbol: BRL1
Gene description: Brl1p
Primary source: FungiDB:YHR036W
Locus tag: YHR036W
See related: SGD:S000001078; AllianceGenome:SGD:S000001078; VEuPathDB:YHR036W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Involved in lipid homeostasis and nuclear envelope organization. Located in endoplasmic reticulum and nuclear envelope. Is integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome VIII - NC_001140.6 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

A perinuclear alpha-helix with amphipathic features in Brl1 promotes NPC assembly.
Title: A perinuclear α-helix with amphipathic features in Brl1 promotes NPC assembly.
A short perinuclear amphipathic alpha-helix in Apq12 promotes nuclear pore complex biogenesis.
Title: A short perinuclear amphipathic α-helix in Apq12 promotes nuclear pore complex biogenesis.
Brr6 and Brl1 transiently associate with nuclear pore complex (NPC) assembly sites where they promote NPC biogenesis.
Title: Brr6 and Brl1 locate to nuclear pore complex assembly sites to promote their biogenesis.
Brl1p functions for nuclear export as a complex with Brr6p
Title: Brl1p -- a novel nuclear envelope protein required for nuclear transport.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in lipid homeostasis	IEA Inferred from Electronic Annotation more info
involved_in lipid homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in lipid homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA transport	IEA Inferred from Electronic Annotation more info
involved_in nuclear envelope organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in nuclear envelope organization	IEA Inferred from Electronic Annotation more info
involved_in nuclear envelope organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	HDA more info	PubMed
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in nuclear envelope	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear envelope	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

NP_011901.1

Essential nuclear envelope/ER integral membrane protein; interacts and functions with Apq12p and Brr6p in lipid homeostasis; mutants are defective in nuclear pore complex biogenesis, mRNA nuclear export and are sensitive to sterol biosynthesis inhibitors and membrane fluidizing agents; identified as a dosage suppressor of a temperature sensitive mutation in the major karyopherin, CRM1; homologous to Brr6p

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The following sections contain reference sequences that belong to a specific genome build. Explain