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PUT2 1-pyrroline-5-carboxylate dehydrogenase [ Saccharomyces cerevisiae S288C ]

Gene ID: 856432, updated on 28-Oct-2024

Summary

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Official Symbol
PUT2
Official Full Name
1-pyrroline-5-carboxylate dehydrogenase
Primary source
SGD:S000001079
Locus tag
YHR037W
See related
AllianceGenome:SGD:S000001079; FungiDB:YHR037W; VEuPathDB:YHR037W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables 1-pyrroline-5-carboxylate dehydrogenase activity. Involved in glutamate biosynthetic process and proline catabolic process to glutamate. Located in mitochondrial matrix. Used to study disease of metabolism. Human ortholog(s) of this gene implicated in hyperprolinemia type 2. Orthologous to human ALDH4A1 (aldehyde dehydrogenase 4 family member A1). [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

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See PUT2 in Genome Data Viewer
Location:
chromosome: VIII
Exon count:
1
Sequence:
Chromosome: VIII; NC_001140.6 (181977..183704)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene GTPase-activating protein NEL1 Neighboring gene Brl1p Neighboring gene Rrf1p Neighboring gene meiotic recombination directing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Proline utilization in Saccharomyces cerevisiae: analysis of the cloned PUT2 gene. Brandriss MC. Mol Cell Biol, 1983 Oct. PMID 6358862, Free PMC Article
  2. Primary structure of the nuclear PUT2 gene involved in the mitochondrial pathway for proline utilization in Saccharomyces cerevisiae. Krzywicki KA, et al. Mol Cell Biol, 1984 Dec. PMID 6098824, Free PMC Article
  3. Role of the yeast acetyltransferase Mpr1 in oxidative stress: regulation of oxygen reactive species caused by a toxic proline catabolism intermediate. Nomura M, et al. Proc Natl Acad Sci U S A, 2004 Aug 24. PMID 15308773, Free PMC Article
  4. Amino-terminal fragments of delta 1-pyrroline-5-carboxylate dehydrogenase direct beta-galactosidase to the mitochondrial matrix in Saccharomyces cerevisiae. Brandriss MC, et al. Mol Cell Biol, 1986 Oct. PMID 3025596, Free PMC Article
  5. Inhibition of yeast 1 -pyrroline-5-carboxylate dehydrogenase by common amino acids and the regulation of proline catabolism. Lundgren DW, et al. Biochim Biophys Acta, 1973 Feb 28. PMID 4145181

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. active site flexibility and oligomeric state of Delta(1)-pyrroline-5-carboxylate dehydrogenase
    Title: Structural studies of yeast Δ(1)-pyrroline-5-carboxylate dehydrogenase (ALDH4A1): active site flexibility and oligomeric state.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables 1-pyrroline-5-carboxylate dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 1-pyrroline-5-carboxylate dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 1-pyrroline-5-carboxylate dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables 1-pyrroline-5-carboxylate dehydrogenase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in glutamate biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proline catabolic process to glutamate IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proline catabolic process to glutamate IEA
Inferred from Electronic Annotation
more info
  
involved_in proline catabolic process to glutamate IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proline metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
1-pyrroline-5-carboxylate dehydrogenase
NP_011902.1
  • Delta-1-pyrroline-5-carboxylate dehydrogenase; nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; deficiency of human homolog ALDH4A1 causes type II hyperprolinemia (HPII), an autosomal recessive inborn error of metabolism; human homolog ALDH4A1 can complement yeast null mutant

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    181977..183704
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179167.1 → NP_011902.1  TPA: 1-pyrroline-5-carboxylate dehydrogenase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011902.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DKY4, P07275
    UniProtKB/TrEMBL
    A6ZSU3, B3LSF7, C7GTU3, C8ZAA7, G2WFA9, N1P2U9
    Conserved Domains (1) summary
    TIGR01236
    Location:29 → 574
    D1pyr5carbox1; delta-1-pyrroline-5-carboxylate dehydrogenase, group 1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P07275.2

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