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RRF1 Rrf1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 856433, updated on 29-Jun-2024

Summary

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Gene symbol
RRF1
Gene description
Rrf1p
Primary source
FungiDB:YHR038W
Locus tag
YHR038W
See related
SGD:S000001080; AllianceGenome:SGD:S000001080; VEuPathDB:YHR038W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
FIL1; KIM4
Summary
Predicted to enable ribosomal large subunit binding activity and translation release factor activity. Involved in mitochondrial translation. Located in mitochondrion. Orthologous to human MRRF (mitochondrial ribosome recycling factor). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See RRF1 in Genome Data Viewer
Location:
chromosome: VIII
Exon count:
1
Sequence:
Chromosome: VIII; NC_001140.6 (184066..184758)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene Brl1p Neighboring gene 1-pyrroline-5-carboxylate dehydrogenase Neighboring gene meiotic recombination directing protein Neighboring gene H(+)-transporting V1 sector ATPase subunit G

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Temperature-sensitive mutation in yeast mitochondrial ribosome recycling factor (RRF). Teyssier E, et al. Nucleic Acids Res, 2003 Jul 15. PMID 12853640, Free PMC Article
  2. A regulatory factor, Fil1p, involved in derepression of the isocitrate lyase gene in Saccharomyces cerevisiae--a possible mitochondrial protein necessary for protein synthesis in mitochondria. Kanai T, et al. Eur J Biochem, 1998 Aug 15. PMID 9746366
  3. New protein functions in yeast chromosome VIII. Ouzounis C, et al. Protein Sci, 1995 Nov. PMID 8563640, Free PMC Article
  4. Chemicals or mutations that target mitochondrial translation can rescue the respiratory deficiency of yeast bcs1 mutants. Panozzo C, et al. Biochim Biophys Acta Mol Cell Res, 2017 Dec. PMID 28888990
  5. Ribosome recycling defects modify the balance between the synthesis and assembly of specific subunits of the oxidative phosphorylation complexes in yeast mitochondria. Ostojić J, et al. Nucleic Acids Res, 2016 Jul 8. PMID 27257059, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. We found that the absence of non-essential translation factors Rrf1 or Mif3, which act at the recycling/initiation steps, also compensates for the respiratory deficiency of yeast bcs1 mutations
    Title: Chemicals or mutations that target mitochondrial translation can rescue the respiratory deficiency of yeast bcs1 mutants.
  2. It has been proposed that Rrf1 takes part in the coordination between translation and oxidative phosphorylation assembly in yeast mitochondria.
    Title: Ribosome recycling defects modify the balance between the synthesis and assembly of specific subunits of the oxidative phosphorylation complexes in yeast mitochondria.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ribosomal large subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation release factor activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
Process Evidence Code Pubs
involved_in mitochondrial translation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
involved_in translational termination IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Rrf1p
NP_011903.1
  • Mitochondrial ribosome recycling factor; essential for mitochondrial protein synthesis and for the maintenance of the respiratory function of mitochondria

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    184066..184758
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179168.1 → NP_011903.1  TPA: Rrf1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011903.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DKY5, P38771
    UniProtKB/TrEMBL
    A0A8H4F9U5, A6ZSU4, B3LSF8, G2WFB0, N1P1K1
    Conserved Domains (1) summary
    COG0233
    Location:45 → 230
    Frr; Ribosome recycling factor [Translation, ribosomal structure and biogenesis]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38771.1

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