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MSC7 meiotic recombination directing protein [ Saccharomyces cerevisiae S288C ]

Gene ID: 856434, updated on 28-Oct-2024

Summary

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Official Symbol
MSC7
Official Full Name
meiotic recombination directing protein
Primary source
SGD:S000001081
Locus tag
YHR039C
See related
AllianceGenome:SGD:S000001081; FungiDB:YHR039C; VEuPathDB:YHR039C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable aldehyde dehydrogenase (NAD+) activity. Involved in reciprocal meiotic recombination. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

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See MSC7 in Genome Data Viewer
Location:
chromosome: VIII
Exon count:
1
Sequence:
Chromosome: VIII; NC_001140.6 (184875..186809, complement)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene 1-pyrroline-5-carboxylate dehydrogenase Neighboring gene Rrf1p Neighboring gene H(+)-transporting V1 sector ATPase subunit G Neighboring gene Bcd1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic control of recombination partner preference in yeast meiosis. Isolation and characterization of mutants elevated for meiotic unequal sister-chromatid recombination. Thompson DA, et al. Genetics, 1999 Oct. PMID 10511544, Free PMC Article
  2. Ltc1 is an ER-localized sterol transporter and a component of ER-mitochondria and ER-vacuole contacts. Murley A, et al. J Cell Biol, 2015 May 25. PMID 25987606, Free PMC Article
  3. ER-to-plasma membrane tethering proteins regulate cell signaling and ER morphology. Manford AG, et al. Dev Cell, 2012 Dec 11. PMID 23237950
  4. Cross-compartment signal propagation in the mitotic exit network. Zhou X, et al. Elife, 2021 Jan 22. PMID 33481703, Free PMC Article
  5. Exo1 recruits Cdc5 polo kinase to MutLγ to ensure efficient meiotic crossover formation. Sanchez A, et al. Proc Natl Acad Sci U S A, 2020 Dec 1. PMID 33199619, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables aldehyde dehydrogenase (NAD+) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in reciprocal meiotic recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
meiotic recombination directing protein
NP_011904.1
  • hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; msc7 mutants are defective in directing meiotic recombination events to homologous chromatids

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    184875..186809 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179169.1 → NP_011904.1  TPA: meiotic recombination directing protein [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011904.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DKY6, P38694
    UniProtKB/TrEMBL
    A6ZSU5, B3LSF9, B5VJX1, C7GTU1, G2WFB1, N1P9M1
    Conserved Domains (1) summary
    cd07098
    Location:115 → 590
    ALDH_F15-22; Aldehyde dehydrogenase family 15A1 and 22A1-like
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38694.1

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