VMA10 H(+)-transporting V1 sector ATPase subunit G [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: VMA10
Official Full Name: H(+)-transporting V1 sector ATPase subunit G
Primary source: SGD:S000002100
Locus tag: YHR039C-A
See related: AllianceGenome:SGD:S000002100; FungiDB:YHR039C-A; VEuPathDB:YHR039C-A
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: YHR039C-B
Summary: Predicted to enable ATP hydrolysis activity and proton-transporting ATPase activity, rotational mechanism. Predicted to be involved in vacuolar acidification. Located in fungal-type vacuole membrane. Part of vacuolar proton-transporting V-type ATPase, V1 domain. Orthologous to several human genes including ATP6V1G1 (ATPase H+ transporting V1 subunit G1). [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

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See VMA10 in Genome Data Viewer

Location:: chromosome: VIII

Exon count:: 2

Sequence:: Chromosome: VIII; NC_001140.6 (187173..187679, complement)

Chromosome VIII - NC_001140.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data indicate the interactions in V-ATPase Vma4 (subunit E) and Vma10 (subunit G).
Title: Probing subunit-subunit interactions in the yeast vacuolar ATPase by peptide arrays.
Data present a structural model of the entire subunit G of V(1)V(O) ATPase.
Title: The NMR solution structure of subunit G (G(61)(-)(101)) of the eukaryotic V1VO ATPase from Saccharomyces cerevisiae.
Domain characterization and interaction of the yeast vacuolar ATPase subunit C with the peripheral stator stalk subunits E and G
Title: Domain characterization and interaction of the yeast vacuolar ATPase subunit C with the peripheral stator stalk subunits E and G.
Solution NMR of the recombinant N- (G(1-59)) and C-terminal segment (G(61-114)) of subunit G, has been performed in the absence and presence of subunit d of the yeast V-ATPase.
Title: Assembly of subunit d (Vma6p) and G (Vma10p) and the NMR solution structure of subunit G (G(1-59)) of the Saccharomyces cerevisiae V(1)V(O) ATPase.
an increase in the level of the TIM23 translocase associated with the cytochrome bc1-COX supercomplex is observed in the absence of Su e and Su g
Title: The F1F0-ATP synthase complex influences the assembly state of the cytochrome bc1-cytochrome oxidase supercomplex and its association with the TIM23 machinery.
Vma10 (subunit G), expressed as a glutathione-S-transferase fusion protein in Escherichia coli, is able to interact strongly with Vma4p (subunit E) expressed in a cell-free system.
Title: Defined sites of interaction between subunits E (Vma4p), C (Vma5p), and G (Vma10p) within the stator structure of the vacuolar H+-ATPase.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables proton-transporting ATPase activity, rotational mechanism	IBA Inferred from Biological aspect of Ancestor more info
enables proton-transporting ATPase activity, rotational mechanism	IEA Inferred from Electronic Annotation more info
enables proton-transporting ATPase activity, rotational mechanism	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in vacuolar acidification	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in fungal-type vacuole membrane	HDA more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in vacuolar membrane	IEA Inferred from Electronic Annotation more info
part_of vacuolar proton-transporting V-type ATPase complex	IEA Inferred from Electronic Annotation more info
part_of vacuolar proton-transporting V-type ATPase, V1 domain	IBA Inferred from Biological aspect of Ancestor more info
part_of vacuolar proton-transporting V-type ATPase, V1 domain	IDA Inferred from Direct Assay more info	PubMed
located_in vacuole	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: H(+)-transporting V1 sector ATPase subunit G

NP_011905.1

Subunit G of the V1 peripheral membrane domain of V-ATPase; part of the electrogenic proton pump found throughout the endomembrane system; involved in vacuolar acidification; the V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase) has eight subunits

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001140.6 Reference assembly

Range

187173..187679 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180027.1 → NP_011905.1 TPA: H(+)-transporting V1 sector ATPase subunit G [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_011905.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D3DKY7, P48836

UniProtKB/TrEMBL

A6ZSU6, C8ZAB0, G2WFB2

Conserved Domains (1) summary

TIGR01147
Location:2 → 112

V_ATP_synt_G; vacuolar ATP synthase, subunit G