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DOG2 2-deoxyglucose-6-phosphatase [ Saccharomyces cerevisiae S288C ]

Gene ID: 856439, updated on 28-Oct-2024

Summary

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Official Symbol
DOG2
Official Full Name
2-deoxyglucose-6-phosphatase
Primary source
SGD:S000001085
Locus tag
YHR043C
See related
AllianceGenome:SGD:S000001085; FungiDB:YHR043C; VEuPathDB:YHR043C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables 2-deoxyglucose-6-phosphatase activity. Involved in glucose metabolic process. Located in cytoplasm and nucleus. Used to study cancer. [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

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See DOG2 in Genome Data Viewer
Location:
chromosome: VIII
Exon count:
1
Sequence:
Chromosome: VIII; NC_001140.6 (192805..193545, complement)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene Srb2p Neighboring gene NADPH--hemoprotein reductase Neighboring gene 2-deoxyglucose-6-phosphatase Neighboring gene Dde1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. DOGR1 and DOGR2: two genes from Saccharomyces cerevisiae that confer 2-deoxyglucose resistance when overexpressed. Randez-Gil F, et al. Yeast, 1995 Oct. PMID 8553694
  2. [High gene conversion frequency between genes encoding 2-deoxyglucose-6-phosphate phosphatase in 3 Saccharomyces species]. Piscopo SP, et al. Genome, 2014 May. PMID 25188289
  3. Purification and characterization of two isoenzymes of DL-glycerol-3-phosphatase from Saccharomyces cerevisiae. Identification of the corresponding GPP1 and GPP2 genes and evidence for osmotic regulation of Gpp2p expression by the osmosensing mitogen-activated protein kinase signal transduction pathway. Norbeck J, et al. J Biol Chem, 1996 Jun 7. PMID 8662716
  4. Involvement of 2-deoxyglucose-6-phosphate phosphatases in facilitating resilience against ionic and osmotic stress in Saccharomyces cerevisiae. Awasthy C, et al. Microbiol Spectr, 2024 Aug 6. PMID 38953324, Free PMC Article
  5. Spontaneous mutations that confer resistance to 2-deoxyglucose act through Hxk2 and Snf1 pathways to regulate gene expression and HXT endocytosis. Soncini SR, et al. PLoS Genet, 2020 Jul. PMID 32673313, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The induction of HAD-like phosphatases by multiple signaling pathways confers resistance to the metabolic inhibitor 2-deoxyglucose.
    Title: The induction of HAD-like phosphatases by multiple signaling pathways confers resistance to the metabolic inhibitor 2-deoxyglucose.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables 2-deoxyglucose-6-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 2-deoxyglucose-6-phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 2-deoxyglucose-6-phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables beta-phosphoglucomutase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glucose metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in nucleus HDA PubMed 

General protein information

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Preferred Names
2-deoxyglucose-6-phosphatase
NP_011909.1
  • 2-deoxyglucose-6-phosphate phosphatase; member of a family of low molecular weight phosphatases, induced by oxidative and osmotic stress, confers 2-deoxyglucose resistance when overexpressed; DOG2 has a paralog, DOG1, that arose from a single-locus duplication; the last half of DOG1 and DOG2 are subject to gene conversions among S. cerevisiae, S. paradoxus, and S. mikatae

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    192805..193545 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179173.1 → NP_011909.1  TPA: 2-deoxyglucose-6-phosphatase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011909.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DKZ1, P38773
    UniProtKB/TrEMBL
    A6ZSV0, C8ZAB4
    Conserved Domains (1) summary
    cd07527
    Location:9 → 231
    HAD_ScGPP-like; subfamily of beta-phosphoglucomutase-like family, similar to Saccharomyces cerevisiae DL-glycerol-3-phosphate phosphatase (GPP1p/ Rhr2p and GPP2p/HOR2p) and 2-deoxyglucose-6-phosphate phosphatase (DOG1p and DOG2p)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38773.1

Gene LinkOut

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