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AAP1 arginine/alanine aminopeptidase [ Saccharomyces cerevisiae S288C ]

Gene ID: 856443, updated on 29-Jun-2024

Summary

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Gene symbol
AAP1
Gene description
arginine/alanine aminopeptidase
Primary source
FungiDB:YHR047C
Locus tag
YHR047C
See related
SGD:S000001089; AllianceGenome:SGD:S000001089; VEuPathDB:YHR047C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
AAP1'
Summary
Predicted to enable metalloaminopeptidase activity; peptide binding activity; and zinc ion binding activity. Involved in glycogen metabolic process and proteolysis. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in cervix carcinoma. Orthologous to several human genes including NPEPPS (aminopeptidase puromycin sensitive). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See AAP1 in Genome Data Viewer
Location:
chromosome: VIII
Exon count:
1
Sequence:
Chromosome: VIII; NC_001140.6 (198740..201310, complement)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene Dde1p Neighboring gene inositol monophosphate 1-phosphatase INM1 Neighboring gene Yhk8p Neighboring gene putative serine hydrolase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Isolation and characterization of AAP1. A gene encoding an alanine/arginine aminopeptidase in yeast. Caprioglio DR, et al. J Biol Chem, 1993 Jul 5. PMID 8100228
  2. Transcriptional profiling shows that Gcn4p is a master regulator of gene expression during amino acid starvation in yeast. Natarajan K, et al. Mol Cell Biol, 2001 Jul. PMID 11390663, Free PMC Article
  3. Origin, conservation, and loss of alternative splicing events that diversify the proteome in Saccharomycotina budding yeasts. Hurtig JE, et al. RNA, 2020 Oct. PMID 32631843, Free PMC Article
  4. Ribosome-Associated Mba1 Escorts Cox2 from Insertion Machinery to Maturing Assembly Intermediates. Lorenzi I, et al. Mol Cell Biol, 2016 Nov 15. PMID 27550809, Free PMC Article
  5. Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII. Johnston M, et al. Science, 1994 Sep 30. PMID 8091229

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables aminopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables aminopeptidase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metalloaminopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in glycogen metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in peptide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus HDA PubMed 

General protein information

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Preferred Names
arginine/alanine aminopeptidase
NP_011913.1
  • Arginine/alanine amino peptidase; overproduction stimulates glycogen accumulation; AAP1 has a paralog, APE2, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    198740..201310 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179177.1 → NP_011913.1  TPA: arginine/alanine aminopeptidase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011913.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DKZ5, P37898
    UniProtKB/TrEMBL
    A0A8H4C0M6, B3LSG6, C7GT86, C8ZAB8, N1P1L5
    Conserved Domains (1) summary
    COG0308
    Location:2 → 844
    PepN; Aminopeptidase N [Amino acid transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P37898.2

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