SFB3 Sfb3p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: SFB3
Official Full Name: Sfb3p
Primary source: SGD:S000001140
Locus tag: YHR098C
See related: AllianceGenome:SGD:S000001140; FungiDB:YHR098C; VEuPathDB:YHR098C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: LST1
Summary: Predicted to enable SNARE binding activity; signal sequence binding activity; and zinc ion binding activity. Involved in COPII-coated vesicle cargo loading. Located in cell periphery; endoplasmic reticulum; and mating projection tip. Part of COPII vesicle coat. Human ortholog(s) of this gene implicated in Cole-Carpenter syndrome. Orthologous to several human genes including SEC24D (SEC24 homolog D, COPII coat complex component). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See SFB3 in Genome Data Viewer

Location:: chromosome: VIII

Exon count:: 1

Sequence:: Chromosome: VIII; NC_001140.6 (299145..301934, complement)

Chromosome VIII - NC_001140.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Lst1 function appears to be conserved because its mammalian homolog, SEC24C, was also required for ER-phagy.
Title: A COPII subunit acts with an autophagy receptor to target endoplasmic reticulum for degradation.
The COPII cargo adaptor Lst1p contributes to membrane scaffolding and protein transport.
Title: Traffic of p24 Proteins and COPII Coat Composition Mutually Influence Membrane Scaffolding.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables SNARE binding	IBA Inferred from Biological aspect of Ancestor more info
enables signal sequence binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables zinc ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in COPII-coated vesicle cargo loading	IBA Inferred from Biological aspect of Ancestor more info
involved_in COPII-coated vesicle cargo loading	IDA Inferred from Direct Assay more info	PubMed
involved_in COPII-coated vesicle cargo loading	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	IEA Inferred from Electronic Annotation more info
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of COPII vesicle coat	IBA Inferred from Biological aspect of Ancestor more info
part_of COPII vesicle coat	IDA Inferred from Direct Assay more info	PubMed
part_of COPII vesicle coat	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in cell periphery	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	HDA more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum exit site	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in mating projection tip	HDA more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Sfb3p

NP_011966.1

Component of the Sec23p-Sfb3p heterodimer of the COPII vesicle coat; COPII coat is required for cargo selection during vesicle formation in ER to Golgi transport; scaffolding function of Lst1p required to generate vesicles that can accommodate difficult cargo proteins that include large oligomeric assemblies and asymmetrically distributed membrane proteins; with Atg40p acts in autophagy of the ER; homologous to Sec24p and Sfb2p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001140.6 Reference assembly

Range

299145..301934 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179228.1 → NP_011966.1 TPA: Sfb3p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_011966.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D3DL48, P38810

UniProtKB/TrEMBL

A6ZT06, G2WFH2, N1P273

Conserved Domains (1) summary

COG5028
Location:1 → 903

COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]