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GEP4 phosphatidylglycerophosphatase [ Saccharomyces cerevisiae S288C ]

Gene ID: 856500, updated on 18-Sep-2024

Summary

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Official Symbol
GEP4
Official Full Name
phosphatidylglycerophosphatase
Primary source
SGD:S000001142
Locus tag
YHR100C
See related
AllianceGenome:SGD:S000001142; FungiDB:YHR100C; VEuPathDB:YHR100C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables phosphatidylglycerophosphatase activity. Involved in cardiolipin biosynthetic process and phosphorylated carbohydrate dephosphorylation. Located in mitochondrial matrix. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See GEP4 in Genome Data Viewer
Location:
chromosome: VIII
Exon count:
1
Sequence:
Chromosome: VIII; NC_001140.6 (314116..314673, complement)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene Sfb3p Neighboring gene histone acetyltransferase TRA1 Neighboring gene Big1p Neighboring gene putative serine/threonine protein kinase KIC1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Isolation and characterization of a phosphatidylglycerophosphate phosphatase1, PGPP1, in Chlamydomonas reinhardtii. Hung CH, et al. Plant Physiol Biochem, 2015 Jul. PMID 25910650
  2. Phosphatidylglycerophosphate phosphatase is required for root growth in Arabidopsis. Lin YC, et al. Biochim Biophys Acta Mol Cell Biol Lipids, 2018 Jun. PMID 29476828
  3. Cardiolipin deficiency causes triacylglycerol accumulation in Saccharomyces cerevisiae. Yadav PK, et al. Mol Cell Biochem, 2017 Oct. PMID 28432553
  4. Genome-Wide Screens in Saccharomyces cerevisiae Highlight a Role for Cardiolipin in Biogenesis of Mitochondrial Outer Membrane Multispan Proteins. Sauerwald J, et al. Mol Cell Biol, 2015 Sep. PMID 26149385, Free PMC Article
  5. Choice of an adequate promoter for efficient complementation in Saccharomyces cerevisiae: a case study. Lo Presti L, et al. Res Microbiol, 2009 Jul-Aug. PMID 19589384

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylglycerophosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylglycerophosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylglycerophosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylglycerophosphatase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables phosphatidylglycerophosphatase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in cardiolipin biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cardiolipin biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phosphatidylglycerol biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
phosphatidylglycerophosphatase
NP_011968.1
  • Mitochondrial phosphatidylglycerophosphatase (PGP phosphatase); dephosphorylates phosphatidylglycerolphosphate to generate phosphatidylglycerol, an essential step during cardiolipin biosynthesis; null mutant is sensitive to tunicamycin, DTT

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    314116..314673 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179230.1 → NP_011968.1  TPA: phosphatidylglycerophosphatase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011968.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DL50, P38812
    UniProtKB/TrEMBL
    A6ZT08, B3LSL5, C7GLY7, C8Z9P3, G2WFH4, N1P9E6
    Conserved Domains (1) summary
    pfam09419
    Location:3 → 166
    PGP_phosphatase; Mitochondrial PGP phosphatase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38812.1

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