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BIG1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856501, updated on 22-Aug-2024

Summary

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Official Symbol
BIG1
Primary source
FungiDB:YHR101C
Locus tag
YHR101C
See related
SGD:S000001143; AllianceGenome:SGD:S000001143; VEuPathDB:YHR101C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in fungal-type cell wall biogenesis. Is integral component of endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See BIG1 in Genome Data Viewer
Location:
chromosome: VIII
Exon count:
2
Sequence:
Chromosome: VIII; NC_001140.6 (314874..315968, complement)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene histone acetyltransferase TRA1 Neighboring gene phosphatidylglycerophosphatase Neighboring gene putative serine/threonine protein kinase KIC1 Neighboring gene Sbe22p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Deletion of the CaBIG1 gene reduces beta-1,6-glucan synthesis, filamentation, adhesion, and virulence in Candida albicans. Umeyama T, et al. Infect Immun, 2006 Apr. PMID 16552067, Free PMC Article
  2. Rot1p of Saccharomyces cerevisiae is a putative membrane protein required for normal levels of the cell wall 1,6-beta-glucan. Machi K, et al. Microbiology (Reading), 2004 Oct. PMID 15470097
  3. Saccharomyces cerevisiae Big1p, a putative endoplasmic reticulum membrane protein required for normal levels of cell wall beta-1,6-glucan. Azuma M, et al. Yeast, 2002 Jun 30. PMID 12112232
  4. ATP6AP1 deficiency causes an immunodeficiency with hepatopathy, cognitive impairment and abnormal protein glycosylation. Jansen EJ, et al. Nat Commun, 2016 May 27. PMID 27231034, Free PMC Article
  5. Osw2 is required for proper assembly of glucan and/or mannan layers of the yeast spore wall. Pan HP, et al. J Biochem, 2018 Apr 1. PMID 29211891

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Deletion of BIG1 does not affect the rate of vegetative growth but does lead to defects in filamentation, adhesion, and virulence in the kidneys of infected mice.
    Title: Deletion of the CaBIG1 gene reduces beta-1,6-glucan synthesis, filamentation, adhesion, and virulence in Candida albicans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in (1->6)-beta-D-glucan biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell wall organization IEA
Inferred from Electronic Annotation
more info
  
involved_in fungal-type cell wall biogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fungal-type cell wall biogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Big1p
NP_011969.1
  • Integral membrane protein of the endoplasmic reticulum; required for normal content of cell wall beta-1,6-glucan

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    314874..315968 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179231.1 → NP_011969.1  TPA: Big1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011969.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DL51, P38813
    UniProtKB/TrEMBL
    A6ZT09, B3LSL6, C8Z9P4
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38813.1

Gene LinkOut

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