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putative cystathionine beta-lyase [ Saccharomyces cerevisiae S288C ]

Gene ID: 856512, updated on 18-Sep-2024

Summary

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Official Full Name
putative cystathionine beta-lyase
Primary source
SGD:S000001154
Locus tag
YHR112C
See related
AllianceGenome:SGD:S000001154; FungiDB:YHR112C; VEuPathDB:YHR112C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable cystathionine beta-lyase activity and pyridoxal phosphate binding activity. Predicted to be involved in transsulfuration. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: VIII
Exon count:
1
Sequence:
Chromosome: VIII; NC_001140.6 (334527..335663, complement)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene Erp5p Neighboring gene Uba4p Neighboring gene aspartyl aminopeptidase Neighboring gene Bzz1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cysteine is essential for transcriptional regulation of the sulfur assimilation genes in Saccharomyces cerevisiae. Hansen J, et al. Mol Gen Genet, 2000 Apr. PMID 10821189
  2. An overexpression screen in Saccharomyces cerevisiae identifies novel genes that affect endocytic protein trafficking. Arlt H, et al. Traffic, 2011 Nov. PMID 21777356
  3. Modeling complex genetic interactions in a simple eukaryotic genome: actin displays a rich spectrum of complex haploinsufficiencies. Haarer B, et al. Genes Dev, 2007 Jan 15. PMID 17167106, Free PMC Article
  4. Comparative analysis of Saccharomyces cerevisiae WW domains and their interacting proteins. Hesselberth JR, et al. Genome Biol, 2006. PMID 16606443, Free PMC Article
  5. Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII. Johnston M, et al. Science, 1994 Sep 30. PMID 8091229

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables carbon-sulfur lyase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-S-conjugate beta-lyase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables pyridoxal phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in sulfur compound metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in transsulfuration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transsulfuration IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
putative cystathionine beta-lyase
NP_011980.1
  • hypothetical protein; localizes to the cytoplasm and nucleus; overexpression affects protein trafficking through the endocytic pathway

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    334527..335663 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179242.1 → NP_011980.1  TPA: putative cystathionine beta-lyase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011980.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DL62, P38716
    UniProtKB/TrEMBL
    A6ZT20, B3LSM7, C7GLZ8, C8Z9Q5, G2WFI6, N1P289
    Conserved Domains (1) summary
    cd00614
    Location:20 → 372
    CGS_like; Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of antimicrobials and ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38716.1

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