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TOM71 protein channel TOM71 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856517, updated on 18-Sep-2024

Summary

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Official Symbol
TOM71
Official Full Name
protein channel TOM71
Primary source
SGD:S000001159
Locus tag
YHR117W
See related
AllianceGenome:SGD:S000001159; FungiDB:YHR117W; VEuPathDB:YHR117W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
TOM72
Summary
Predicted to enable protein transmembrane transporter activity. Involved in protein targeting to mitochondrion. Located in mitochondrial outer membrane. Is integral component of mitochondrial outer membrane. Human ortholog(s) of this gene implicated in congestive heart failure. Orthologous to human TOMM70 (translocase of outer mitochondrial membrane 70). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See TOM71 in Genome Data Viewer
Location:
chromosome: VIII
Exon count:
1
Sequence:
Chromosome: VIII; NC_001140.6 (342349..344268)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene ubiquitin-conjugating protein DMA1 Neighboring gene Cox23p Neighboring gene origin recognition complex subunit 6 Neighboring gene histone methyltransferase SET1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of a third yeast mitochondrial Tom protein with tetratrico peptide repeats. Bömer U, et al. FEBS Lett, 1996 Mar 11. PMID 8612740
  2. Tom71, a novel homologue of the mitochondrial preprotein receptor Tom70. Schlossmann J, et al. J Biol Chem, 1996 Jul 26. PMID 8663394
  3. The C-terminal TPR domain of Tom70 defines a family of mitochondrial protein import receptors found only in animals and fungi. Chan NC, et al. J Mol Biol, 2006 May 12. PMID 16566938
  4. The structural plasticity of Tom71 for mitochondrial precursor translocations. Li J, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2010 Sep 1. PMID 20823510, Free PMC Article
  5. Tetratricopeptide repeat proteins Tom70 and Tom71 mediate yeast mitochondrial morphogenesis. Kondo-Okamoto N, et al. EMBO Rep, 2008 Jan. PMID 18007655, Free PMC Article

See all (57) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. domain rearrangements in Tom71 significantly change the surface hydrophobicity and the volume of the precursor-binding pocket
    Title: The structural plasticity of Tom71 for mitochondrial precursor translocations.
  2. The complex formation between the C-terminal motif of Hsp70/Hsp90 and Tom71 could lock Tom71 in the open state where the preprotein-binding pocket of Tom71 is ready to receive preproteins.
    Title: Molecular chaperone Hsp70/Hsp90 prepares the mitochondrial outer membrane translocon receptor Tom71 for preprotein loading.
  3. These data indicate an unexpected role for Tom70 in recruitment of soluble proteins to the mitochondrial surface, and indicate that Tom71 has a specialized role in Mfb1-mediated mitochondrial morphogenesis.
    Title: Tetratricopeptide repeat proteins Tom70 and Tom71 mediate yeast mitochondrial morphogenesis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables mitochondrion targeting sequence binding IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to protein transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein import into mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein insertion into mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein targeting to mitochondrion IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein targeting to mitochondrion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrial outer membrane HDA PubMed 
is_active_in mitochondrial outer membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein channel TOM71
NP_011985.1
  • Mitochondrial outer membrane protein; probable minor component of the TOM (translocase of outer membrane) complex responsible for recognition and import of mitochondrially directed proteins; TOM71 has a paralog, TOM70, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    342349..344268
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179247.1 → NP_011985.1  TPA: protein channel TOM71 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011985.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DL67, P38825
    UniProtKB/TrEMBL
    C7GR63, N1P153
    Conserved Domains (2) summary
    TIGR00990
    Location:9 → 636
    3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
    sd00006
    Location:127 → 155
    TPR; TPR repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38825.1

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