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ARP1 actin-related protein 1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856530, updated on 2-Nov-2024

Summary

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Official Symbol
ARP1
Official Full Name
actin-related protein 1
Primary source
SGD:S000001171
Locus tag
YHR129C
See related
AllianceGenome:SGD:S000001171; FungiDB:YHR129C; VEuPathDB:YHR129C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
ACT5
Summary
A structural constituent of cytoskeleton. Involved in establishment of mitotic spindle orientation; mitotic spindle orientation checkpoint signaling; and nuclear migration. Part of dynactin complex. Orthologous to several human genes including ACTR1B (actin related protein 1B). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ARP1 in Genome Data Viewer
Location:
chromosome: VIII
Exon count:
1
Sequence:
Chromosome: VIII; NC_001140.6 (362999..364153, complement)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uracil phosphoribosyltransferase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cloning and identification of Arp1, an actin-related protein from Pneumocystis carinii. Christopher LJ, et al. J Eukaryot Microbiol, 1995 Mar-Apr. PMID 7757056
  2. ACT3: a putative centractin homologue in S. cerevisiae is required for proper orientation of the mitotic spindle. Clark SW, et al. J Cell Biol, 1994 Oct. PMID 7929558, Free PMC Article
  3. Molecular dissection of ARP1 regions required for nuclear migration and cell wall integrity checkpoint functions in Saccharomyces cerevisiae. Igarashi R, et al. Cell Struct Funct, 2005. PMID 16415535
  4. A yeast actin-related protein homologous to that in vertebrate dynactin complex is important for spindle orientation and nuclear migration. Muhua L, et al. Cell, 1994 Aug 26. PMID 8069915
  5. Alanine scanning of Arp1 delineates a putative binding site for Jnm1/dynamitin and Nip100/p150Glued. Clark SW, et al. Mol Biol Cell, 2005 Sep. PMID 15975903, Free PMC Article

See all (79) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables structural constituent of cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in establishment of mitotic spindle orientation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic spindle orientation checkpoint signaling IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in nuclear migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
part_of dynactin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of dynactin complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of dynein complex IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular non-membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
actin-related protein 1
NP_011997.1
  • Actin-related protein of the dynactin complex; required for spindle orientation and nuclear migration; forms actin-like short filament composed of 9 or 10 Arp1p monomers; putative ortholog of mammalian centractin

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    362999..364153 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179259.1 → NP_011997.1  TPA: actin-related protein 1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011997.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DL78, P38696, Q6B1J6
    UniProtKB/TrEMBL
    B3LSP3, B5VK62, C7GR73, C8Z9S2, G2WFK2, N1P2U0
    Conserved Domains (1) summary
    smart00268
    Location:12 → 384
    ACTIN; Actin
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38696.1

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