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DCD1 deoxycytidine monophosphate deaminase [ Saccharomyces cerevisiae S288C ]

Gene ID: 856548, updated on 2-Nov-2024

Summary

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Official Symbol
DCD1
Official Full Name
deoxycytidine monophosphate deaminase
Primary source
SGD:S000001187
Locus tag
YHR144C
See related
AllianceGenome:SGD:S000001187; FungiDB:YHR144C; VEuPathDB:YHR144C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables dCMP deaminase activity. Involved in dTMP biosynthetic process and dUMP biosynthetic process. Located in cytoplasm. Orthologous to human DCTD (dCMP deaminase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See DCD1 in Genome Data Viewer
Location:
chromosome: VIII
Exon count:
1
Sequence:
Chromosome: VIII; NC_001140.6 (387788..388726, complement)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene Dse2p Neighboring gene DNA-directed RNA polymerase core subunit RPC10 Neighboring gene tRNA-Pro Neighboring gene Crp1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Involvement of deoxycytidylate deaminase in the response to S(n)1-type methylation DNA damage in budding yeast. Liskay RM, et al. Curr Biol, 2007 Sep 4. PMID 17803923, Free PMC Article
  2. Mutational specificity of DNA precursor pool imbalances in yeast arising from deoxycytidylate deaminase deficiency or treatment with thymidylate. Kohalmi SE, et al. J Mol Biol, 1991 Aug 20. PMID 1880805
  3. Sequence and expression of the dCMP deaminase gene (DCD1) of Saccharomyces cerevisiae. McIntosh EM, et al. Mol Cell Biol, 1986 May. PMID 3023902, Free PMC Article
  4. Isolation of a Saccharomyces cerevisiae mutant strain deficient in deoxycytidylate deaminase activity and partial characterization of the enzyme. McIntosh EM, et al. J Bacteriol, 1984 May. PMID 6373725, Free PMC Article
  5. Elevated intracellular dCTP levels reduce the induction of GC-->AT transitions in yeast by ethyl methanesulfonate or N-methyl-N'-nitro-N- nitrosoguanidine but increase alkylation-induced GC-->CG transversions. Kohalmi SE, et al. Mutagenesis, 1993 Sep. PMID 8231828

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables dCMP deaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dCMP deaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables dCMP deaminase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables deaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in cytidine deamination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in dTMP biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dUMP biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nucleobase-containing compound biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
deoxycytidine monophosphate deaminase
NP_012014.1
  • Deoxycytidine monophosphate (dCMP) deaminase; involved in dUMP and dTMP biosynthesis; expression is NOT cell cycle regulated

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    387788..388726 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179275.1 → NP_012014.1  TPA: deoxycytidine monophosphate deaminase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012014.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DL94, P06773
    UniProtKB/TrEMBL
    A6ZT53, B3LSQ9, C7GXW5, G2WFL8, N1P2C6
    Conserved Domains (1) summary
    COG2131
    Location:159 → 312
    ComEB; Deoxycytidylate deaminase [Nucleotide transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P06773.2

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