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MTC6 Mtc6p [ Saccharomyces cerevisiae S288C ]

Gene ID: 856556, updated on 2-Nov-2024

Summary

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Official Symbol
MTC6
Official Full Name
Mtc6p
Primary source
SGD:S000001194
Locus tag
YHR151C
See related
AllianceGenome:SGD:S000001194; FungiDB:YHR151C; VEuPathDB:YHR151C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in cellular response to hydrostatic pressure. Located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See MTC6 in Genome Data Viewer
Location:
chromosome: VIII
Exon count:
1
Sequence:
Chromosome: VIII; NC_001140.6 (399268..400848, complement)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene Skg6p Neighboring gene Pex28p Neighboring gene Spo12p Neighboring gene Spo16p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mtc6/Ehg2 is a novel endoplasmic reticulum-resident glycoprotein essential for high-pressure tolerance. Uemura S, et al. J Biochem, 2024 Jul 31. PMID 38621657
  2. Role of a novel endoplasmic reticulum-resident glycoprotein Mtc6/Ehg2 in high-pressure growth: stability of tryptophan permease Tat2 in Saccharomyces cerevisiae. Kato Y, et al. Biosci Biotechnol Biochem, 2024 Aug 26. PMID 38918055
  3. Early steps in autophagy depend on direct phosphorylation of Atg9 by the Atg1 kinase. Papinski D, et al. Mol Cell, 2014 Feb 6. PMID 24440502, Free PMC Article
  4. Screening the yeast "disruptome" for mutants affecting resistance to the immunosuppressive drug, mycophenolic acid. Desmoucelles C, et al. J Biol Chem, 2002 Jul 26. PMID 12016207
  5. Identification of genes affecting vacuole membrane fragmentation in Saccharomyces cerevisiae. Michaillat L, et al. PLoS One, 2013. PMID 23383298, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in cellular response to hydrostatic pressure IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Mtc6p
NP_012021.1
  • ER-resident glycoprotein involved in high-pressure tolerance; proposed role promoting proper folding of nutrient permeases in the ER during hydrostatic pressure stress; contains two transmembrane domains, a C-terminal cytoplasmic domain and a luminal region containing 12 N-linked glycans; null mutant is synthetically sick with cdc13-1; SWAT-GFP and mCherry fusion proteins localize to the vacuole while SWAT-GFP fusion also localizes to the endoplasmic reticulum

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    399268..400848 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179282.1 → NP_012021.1  TPA: Mtc6p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012021.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A6ZT59, B3LSR5, B5VK80, C8Z9U8, D3DLA0, P38849
    UniProtKB/TrEMBL
    G2WFM4, N1P9G6
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38849.1

Gene LinkOut

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