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SPO12 Spo12p [ Saccharomyces cerevisiae S288C ]

Gene ID: 856557, updated on 18-Sep-2024

Summary

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Official Symbol
SPO12
Official Full Name
Spo12p
Primary source
SGD:S000001195
Locus tag
YHR152W
See related
AllianceGenome:SGD:S000001195; FungiDB:YHR152W; VEuPathDB:YHR152W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
SDB21
Summary
Involved in meiosis I; negative regulation of protein localization to nucleolus; and positive regulation of exit from mitosis. Located in nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See SPO12 in Genome Data Viewer
Location:
chromosome: VIII
Exon count:
1
Sequence:
Chromosome: VIII; NC_001140.6 (401434..401955)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene Pex28p Neighboring gene Mtc6p Neighboring gene Spo16p Neighboring gene Rtt107p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A new mapping method employing a meiotic rec-mutant of yeast. Klapholz S, et al. Genetics, 1982 Mar. PMID 6749597, Free PMC Article
  2. The HECT-type ubiquitin ligase Tom1 contributes to the turnover of Spo12, a component of the FEAR network, in G2/M phase. Nakatsukasa K, et al. FEBS Lett, 2018 May. PMID 29683484
  3. Genetic analysis of apomictic wine yeasts. Castrejón F, et al. Curr Genet, 2004 Apr. PMID 14760507
  4. Nuclear import of Spo12p, a protein essential for meiosis. Chaves SR, et al. J Biol Chem, 2001 May 25. PMID 11278742
  5. A cdc-like autolytic Saccharomyces cerevisiae mutant altered in budding site selection is complemented by SPO12, a sporulation gene. Molero G, et al. J Bacteriol, 1993 Oct. PMID 8407833, Free PMC Article

See all (87) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Notably, Spo12 is degraded in S phase even in the absence of Tom1 and Cdh1, suggesting that an additional E3 ligase(s) also mediates Spo12 degradation
    Title: The HECT-type ubiquitin ligase Tom1 contributes to the turnover of Spo12, a component of the FEAR network, in G2/M phase.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in meiosis I IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of protein localization to nucleolus IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of protein localization to nucleolus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of exit from mitosis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of exit from mitosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sporulation resulting in formation of a cellular spore IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Spo12p
NP_012022.1
  • Nucleolar hypothetical protein; positive regulator of mitotic exit; involved in regulating release of Cdc14p from the nucleolus in early anaphase, may play similar role in meiosis; SPO12 has a paralog, BNS1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    401434..401955
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179283.1 → NP_012022.1  TPA: Spo12p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012022.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DLA1, P17123
    UniProtKB/TrEMBL
    A6ZT60, B3LSR6, B5VK81, C7GJY6, C8Z9U9, N1P2W4
    Conserved Domains (1) summary
    pfam05032
    Location:117 → 151
    Spo12; Spo12 family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P17123.1

Gene LinkOut

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