RTT107 Rtt107p [Saccharomyces cerevisiae S288C] - Gene

Summary

Go to the top of the page Help

Official Symbol: RTT107
Official Full Name: Rtt107p
Primary source: SGD:S000001197
Locus tag: YHR154W
See related: AllianceGenome:SGD:S000001197; FungiDB:YHR154W; VEuPathDB:YHR154W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: ESC4
Summary: Enables chromatin binding activity. Involved in several processes, including DNA double-strand break attachment to nuclear envelope; regulation of DNA damage checkpoint; and regulation of DNA double-strand break processing. Located in cell periphery and nucleus. Part of Cul8-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Nov 2024]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See RTT107 in Genome Data Viewer

Location:: chromosome: VIII

Exon count:: 1

Sequence:: Chromosome: VIII; NC_001140.6 (402966..406178)

Chromosome VIII - NC_001140.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Functional studies show that Rtt107 binding of partner proteins of diverse activities promotes genome replication and stability in both distinct and concerted manners. A unified theme is that tetra- and di-BRCT domains of Rtt107 collaborate to recruit partner proteins to chromatin
Title: Molecular Basis for Control of Diverse Genome Stability Factors by the Multi-BRCT Scaffold Rtt107.
Rtt107 prevents checkpoint hyperactivation after replicative stress by limiting DNA damage
Title: Budding yeast Rtt107 prevents checkpoint hyperactivation after replicative stress by limiting DNA damage.
The scaffold protein Rtt107, which binds the Mus81-Mms4 complex, interacts with Cdc7 and thereby targets Cdc7-Dbf4 and Cdc5 to the complex enabling full Mus81 activation.
Title: Dbf4-dependent kinase and the Rtt107 scaffold promote Mus81-Mms4 resolvase activation during mitosis.
A key function of the Rtt107 BRCT domains for targeting of both itself and its interaction partners to DNA lesions was revealed.
Title: Rtt107 BRCT domains act as a targeting module in the DNA damage response.
Slx4 and Rtt107 control checkpoint signalling and DNA resection at double-strand breaks.
Title: Slx4 and Rtt107 control checkpoint signalling and DNA resection at double-strand breaks.
Rtt107 is a multi-functional scaffold supporting replication progression with partners SUMO, ubiquitin ligase E3, and SLX4.
Title: Rtt107 Is a Multi-functional Scaffold Supporting Replication Progression with Partner SUMO and Ubiquitin Ligases.
The DNA repair scaffold proteins Slx4 and Rtt107 utilize a minimal multi-BRCT-domain module for phosphatase-independent downregulation of DNA damage response signals in yeast.
Title: Dampening DNA damage checkpoint signalling via coordinated BRCT domain interactions.
The C-terminal tandem BRCT repeats of Rtt107 interaction with gammaH2A is functionally important during DNA repair.
Title: Structure of C-terminal tandem BRCT repeats of Rtt107 protein reveals critical role in interaction with phosphorylated histone H2A during DNA damage repair.
a multifaceted functional relationship between Rtt107 and Dot1 in the DNA damage response and maintenance of genome integrity.
Title: Loss of H3 K79 trimethylation leads to suppression of Rtt107-dependent DNA damage sensitivity through the translesion synthesis pathway.
Multiple fork repair factors associate with Rtt107 or Slx4, supporting that Mec1-dependent assembly of the Rtt107-Slx4-Dpb11 complex functions to coordinate fork repair.
Title: DNA damage signaling recruits the Rtt107-Slx4 scaffolds via Dpb11 to mediate replication stress response.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA double-strand break attachment to nuclear envelope	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA double-strand break attachment to nuclear envelope	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in double-strand break repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in double-strand break repair	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA damage checkpoint	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA double-strand break processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in retrotransposon silencing	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Cul8-RING ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Cul8-RING ubiquitin ligase complex	IDA Inferred from Direct Assay more info	PubMed
located_in cell periphery	HDA more info	PubMed
located_in nucleus	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: Rtt107p

NP_012024.1

BRCA1 C-terminal domain protein needed for recovery from DNA damage; implicated in Mms22-dependent DNA repair during S phase; involved in recruiting SMC5/6 complex to double-strand breaks; DNA damage induces phosphorylation by Mec1p at one or more SQ/TQ motifs; interacts with Mms22p and Slx4p; has four BRCT domains; has a role in regulation of Ty1 transposition; relative distribution to nuclear foci increases upon DNA replication stress

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001140.6 Reference assembly

Range

402966..406178

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179285.1 → NP_012024.1 TPA: Rtt107p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012024.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D3DLA3, P38850

UniProtKB/TrEMBL

G2WFM7, N1P2D3

Conserved Domains (5) summary

PTZ00121
Location:580 → 824

PTZ00121; MAEBL; Provisional

pfam00533
Location:117 → 213

BRCT; BRCA1 C-terminus (BRCT) domain

pfam16770
Location:830 → 914

RTT107_BRCT_5; Regulator of Ty1 transposition protein 107 BRCT domain

pfam16771
Location:948 → 1054

RTT107_BRCT_6; Regulator of Ty1 transposition protein 107 BRCT domain

cl00038
Location:382 → 456

BRCT; C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains