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ENO2 phosphopyruvate hydratase ENO2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856579, updated on 3-Nov-2024

Summary

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Official Symbol
ENO2
Official Full Name
phosphopyruvate hydratase ENO2
Primary source
SGD:S000001217
Locus tag
YHR174W
See related
AllianceGenome:SGD:S000001217; FungiDB:YHR174W; VEuPathDB:YHR174W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables melatonin binding activity and phosphopyruvate hydratase activity. Involved in glycolytic process and regulation of vacuole fusion, non-autophagic. Located in cytoplasmic side of plasma membrane; fungal-type vacuole; and mitochondrion. Part of phosphopyruvate hydratase complex. Human ortholog(s) of this gene implicated in Alzheimer's disease and prostate cancer. Orthologous to several human genes including ENO1 (enolase 1) and ENO3 (enolase 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ENO2 in Genome Data Viewer
Location:
chromosome: VIII
Exon count:
1
Sequence:
Chromosome: VIII; NC_001140.6 (451327..452640)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene Spc97p Neighboring gene uncharacterized protein Neighboring gene low-affinity Cu transporter Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A glycolytic enzyme, enolase, is recruited as a cofactor of tRNA targeting toward mitochondria in Saccharomyces cerevisiae. Entelis N, et al. Genes Dev, 2006 Jun 15. PMID 16738406, Free PMC Article
  2. Identification of a regulatory region that mediates glucose-dependent induction of the Saccharomyces cerevisiae enolase gene ENO2. Cohen R, et al. Mol Cell Biol, 1986 Jul. PMID 3537717, Free PMC Article
  3. Role of metal ions in catalysis by enolase: an ordered kinetic mechanism for a single substrate enzyme. Poyner RR, et al. Biochemistry, 2001 Jul 10. PMID 11434770
  4. Characterization of differently processed forms of enolase 2 from Saccharomyces cerevisiae by two-dimensional gel electrophoresis and mass spectrometry. Larsen MR, et al. Electrophoresis, 2001 Feb. PMID 11258770
  5. Crystal structure of enolase indicates that enolase and pyruvate kinase evolved from a common ancestor. Lebioda L, et al. Nature, 1988 Jun 16. PMID 3374614

See all (171) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. data suggest the existence of a protein complex containing Eno2p that is involved in RNA mitochondrial import
    Title: Factors beyond Enolase 2 and Mitochondrial Lysyl-tRNA Synthetase Precursor Are Required for tRNA Import into Yeast Mitochondria.
  2. Both novel and known locus-specific DNA-protein interactions were identified at the ENO2 and GAL1 promoter regions of Saccharomyces cerevisiae, and revealed subgroups of proteins present in significantly different levels at the loci in cells grown on glucose versus galactose as the carbon source
    Title: HyCCAPP as a tool to characterize promoter DNA-protein interactions in Saccharomyces cerevisiae.
  3. The results indicate an alternative molecular chaperone function of glycolytic enzyme enolase in tRNA mitochondrial targeting.
    Title: A glycolytic enzyme, enolase, is recruited as a cofactor of tRNA targeting toward mitochondria in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables melatonin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphopyruvate hydratase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphopyruvate hydratase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphopyruvate hydratase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in glycolytic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycolytic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycolytic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of vacuole fusion, non-autophagic IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of vacuole fusion, non-autophagic IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol HDA PubMed 
located_in fungal-type vacuole IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
part_of phosphopyruvate hydratase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of phosphopyruvate hydratase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of phosphopyruvate hydratase complex IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane HDA PubMed 

General protein information

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Preferred Names
phosphopyruvate hydratase ENO2
NP_012044.1
  • Enolase II, a phosphopyruvate hydratase; catalyzes conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; mRNA is asymmetrically distributed to daughter cells in a Sir2p-dependent manner, and asymmetry is lost during replicative aging; expression induced in response to glucose; ENO2 has a paralog, ENO1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    451327..452640
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179305.1 → NP_012044.1  TPA: phosphopyruvate hydratase ENO2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012044.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DLC2, P00925, P99013
    UniProtKB/TrEMBL
    A6ZT81, B3LST6, B5VJJ6, G2WFP7
    Conserved Domains (1) summary
    PTZ00081
    Location:1 → 430
    PTZ00081; enolase; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P00925.2

Gene LinkOut

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