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GPI16 GPI-anchor transamidase subunit GPI16 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856595, updated on 2-Nov-2024

Summary

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Official Symbol
GPI16
Official Full Name
GPI-anchor transamidase subunit GPI16
Primary source
SGD:S000001231
Locus tag
YHR188C
See related
AllianceGenome:SGD:S000001231; FungiDB:YHR188C; VEuPathDB:YHR188C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in attachment of GPI anchor to protein. Located in endoplasmic reticulum membrane. Part of GPI-anchor transamidase complex. Human ortholog(s) of this gene implicated in multiple congenital anomalies-hypotonia-seizures syndrome 3 and paroxysmal nocturnal hemoglobinuria. Orthologous to human PIGT (phosphatidylinositol glycan anchor biosynthesis class T). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See GPI16 in Genome Data Viewer
Location:
chromosome: VIII
Exon count:
1
Sequence:
Chromosome: VIII; NC_001140.6 (482005..483837, complement)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene ubiquitin-binding TORC1 subunit KOG1 Neighboring gene Elongator subunit IKI1 Neighboring gene aminoacyl-tRNA hydrolase Neighboring gene bifunctional farnesyl-diphosphate farnesyltransferase/squalene synthase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The GPI transamidase complex of Saccharomyces cerevisiae contains Gaa1p, Gpi8p, and Gpi16p. Fraering P, et al. Mol Biol Cell, 2001 Oct. PMID 11598210, Free PMC Article
  2. A Soluble, Minimalistic Glycosylphosphatidylinositol Transamidase (GPI-T) Retains Transamidation Activity. Ness TJ, et al. Biochemistry, 2022 Jul 5. PMID 35730892
  3. Gpi17p does not stably interact with other subunits of glycosylphosphatidylinositol transamidase in Saccharomyces cerevisiae. Zhu Y, et al. Biochim Biophys Acta, 2005 Jun 15. PMID 15939668
  4. Disulfide Bond Formation and N-Glycosylation Modulate Protein-Protein Interactions in GPI-Transamidase (GPIT). Yi L, et al. Sci Rep, 2017 Apr 4. PMID 28374821, Free PMC Article
  5. PIG-S and PIG-T, essential for GPI anchor attachment to proteins, form a complex with GAA1 and GPI8. Ohishi K, et al. EMBO J, 2001 Aug 1. PMID 11483512, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in GPI anchor biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in attachment of GPI anchor to protein IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in attachment of GPI anchor to protein IEA
Inferred from Electronic Annotation
more info
  
involved_in attachment of GPI anchor to protein IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of GPI-anchor transamidase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of GPI-anchor transamidase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of GPI-anchor transamidase complex IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
GPI-anchor transamidase subunit GPI16
NP_012058.1
  • Subunit of the glycosylphosphatidylinositol transamidase complex; involved in the addition of GPIs to newly synthesized proteins; luminally-oriented, type I integral membrane glycoprotein of the ER; human PIG-T homolog

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    482005..483837 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179319.1 → NP_012058.1  TPA: GPI-anchor transamidase subunit GPI16 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012058.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DLD6, P38875
    UniProtKB/TrEMBL
    A6ZT94, B3LSU9, C7GRL0, C8Z9Y7
    Conserved Domains (1) summary
    pfam04113
    Location:35 → 589
    Gpi16; Gpi16 subunit, GPI transamidase component
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38875.2

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