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PTH1 aminoacyl-tRNA hydrolase [ Saccharomyces cerevisiae S288C ]

Gene ID: 856596, updated on 2-Nov-2024

Summary

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Official Symbol
PTH1
Official Full Name
aminoacyl-tRNA hydrolase
Primary source
SGD:S000001232
Locus tag
YHR189W
See related
AllianceGenome:SGD:S000001232; FungiDB:YHR189W; VEuPathDB:YHR189W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables aminoacyl-tRNA hydrolase activity. Involved in mitochondrial translation. Located in mitochondrion. Orthologous to human PTRH1 (peptidyl-tRNA hydrolase 1 homolog). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See PTH1 in Genome Data Viewer
Location:
chromosome: VIII
Exon count:
1
Sequence:
Chromosome: VIII; NC_001140.6 (484028..484600)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene Elongator subunit IKI1 Neighboring gene GPI-anchor transamidase subunit GPI16 Neighboring gene bifunctional farnesyl-diphosphate farnesyltransferase/squalene synthase Neighboring gene Ctf8p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Enzymatic hydrolysis of N-substituted aminoacyl transfer ribonucleic acid in yeast. Jost JP, et al. J Biol Chem, 1969 Nov 10. PMID 4981785
  2. New protein functions in yeast chromosome VIII. Ouzounis C, et al. Protein Sci, 1995 Nov. PMID 8563640, Free PMC Article
  3. Peptidyl-tRNA hydrolase from Sulfolobus solfataricus. Fromant M, et al. Nucleic Acids Res, 2003 Jun 15. PMID 12799450, Free PMC Article
  4. Membrane rafts are involved in intracellular miconazole accumulation in yeast cells. François IE, et al. J Biol Chem, 2009 Nov 20. PMID 19783660, Free PMC Article
  5. Peptidyl-tRNA hydrolase in Bacillus subtilis, encoded by spoVC, is essential to vegetative growth, whereas the homologous enzyme in Saccharomyces cerevisiae is dispensable. Menez J, et al. Mol Microbiol, 2002 Jul. PMID 12100553

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables aminoacyl-tRNA hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aminoacyl-tRNA hydrolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables aminoacyl-tRNA hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables aminoacyl-tRNA hydrolase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mitochondrial translation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
aminoacyl-tRNA hydrolase
NP_012059.3
  • One of two mitochondrially-localized peptidyl-tRNA hydrolases; dispensable for respiratory growth on rich medium, but required for respiratory growth on minimal medium; see also PTH2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    484028..484600
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179320.3 → NP_012059.3  TPA: aminoacyl-tRNA hydrolase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012059.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DLD7, P38876
    UniProtKB/TrEMBL
    A6ZT95, B3LSV0, C7GRL1, C8Z9Y8, G2WFR2, N1P9I3
    Conserved Domains (1) summary
    TIGR00447
    Location:6 → 190
    pth; aminoacyl-tRNA hydrolase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38876.1

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