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SMN1 Smn1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 856609, updated on 17-May-2024

Summary

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Gene symbol
SMN1
Gene description
Smn1p
Primary source
FungiDB:YHR202W
Locus tag
YHR202W
See related
SGD:S000001245; AllianceGenome:SGD:S000001245; VEuPathDB:YHR202W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable hydrolase activity. Predicted to be involved in nucleotide catabolic process. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See SMN1 in Genome Data Viewer
Location:
chromosome: VIII
Exon count:
1
Sequence:
Chromosome: VIII; NC_001140.6 (502388..504196)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene proteasome regulatory particle base subunit RPN10 Neighboring gene exopolyphosphatase Neighboring gene ribosomal 40S subunit protein S4B Neighboring gene alpha-1,2-mannosidase MNL1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A Similarity-Based Method for Predicting Enzymatic Functions in Yeast Uncovers a New AMP Hydrolase. Cohen N, et al. J Mol Biol, 2022 Apr 15. PMID 35123996, Free PMC Article
  2. Low affinity orthophosphate carriers regulate PHO gene expression independently of internal orthophosphate concentration in Saccharomyces cerevisiae. Pinson B, et al. J Biol Chem, 2004 Aug 20. PMID 15194704
  3. A strategy for interaction site prediction between phospho-binding modules and their partners identified from proteomic data. Aucher W, et al. Mol Cell Proteomics, 2010 Dec. PMID 20733106, Free PMC Article
  4. Sequence-based approach for identification of cell wall proteins in Saccharomyces cerevisiae. Terashima H, et al. Curr Genet, 2002 Feb. PMID 11935221
  5. Srs2 and Sgs1 DNA helicases associate with Mre11 in different subcomplexes following checkpoint activation and CDK1-mediated Srs2 phosphorylation. Chiolo I, et al. Mol Cell Biol, 2005 Jul. PMID 15964827, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A Similarity-Based Method for Predicting Enzymatic Functions in Yeast Uncovers a New AMP Hydrolase.
    Title: A Similarity-Based Method for Predicting Enzymatic Functions in Yeast Uncovers a New AMP Hydrolase.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables 5'-nucleotidase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in NAD catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nucleotide catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in extracellular region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in fungal-type vacuole HDA PubMed 
located_in vacuole IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Smn1p
NP_012072.3
  • Putative AMP hydrolase; secreted protein proposed to function as an adenosine monophosphatase in NAD+ degradation, via nucleoside salvage pathway that converts NAD+ to AMP and adenosine; overexpression results in adenosine accumulation and reduced levels of NAD+, deletion results in increased NAD+ and NADH; targeted to vacuole via Vps10p-dependent endosomal vacuolar protein sorting pathway; similar to human NT5E/CD73 gene involved in cancer progression

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    502388..504196
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179333.3 → NP_012072.3  TPA: Smn1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012072.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DLF1, P38887
    UniProtKB/TrEMBL
    A0A8H4BZU0, A6ZTA9, B3LSW3, C8ZA03, N1P320
    Conserved Domains (1) summary
    cd07407
    Location:39 → 325
    MPP_YHR202W_N; Saccharomyces cerevisiae YHR202W and related proteins, N-terminal metallophosphatase domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38887.1

Gene LinkOut

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